5256-76-8

Basic information

• Product Name: L-Arginine 2-oxopentanedioate
• Synonyms: l-arginine 2-oxopentanedioate;L-ARGININE A-KETOGLUTARATE (2:1);L-ARGININE ALPHA-KETOGLUTARATE (2:1);L-ARGININE ALPHA-KETOGLUTARATE(2:1) DIHYDRATE;L-ARGININE-ALPHA-KETOGLUTARIC ACID SALT(2:1) DIHYDRATE;L-Arginine AKG 2:1;L-Arginine alpha-Ketoglutarate Dihydrate;di-L-arginine 2-oxoglutarate
• CAS NO: 5256-76-8
• Molecular Formula: C17H38N8O11
• Molecular Weight: 530.53
• EINECS: 226-059-4
• Product Categories: Amino Acids;Nutritional Supplements;Food Additives;amino acid
• Mol File: 5256-76-8.mol

Chemical Properties

• Boiling Point: 914.9oC at 760 mmHg
• Flash Point: 507.1oC
• Appearance: /
• Vapor Pressure: 0mmHg at 25°C
• CAS DataBase Reference: L-Arginine 2-oxopentanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: L-Arginine 2-oxopentanedioate(5256-76-8)
• EPA Substance Registry System: L-Arginine 2-oxopentanedioate(5256-76-8)

Safety Data

• Hazardous Substances Data: 5256-76-8(Hazardous Substances Data)

Usage

Uses

Used in Cardiovascular Health Applications:
L-Arginine 2-oxopentanedioate is used as a cardiovascular health enhancer for its potential to improve circulation by increasing nitric oxide production, which helps relax blood vessels and promote better blood flow.
Used in Exercise Performance Applications:
In the field of sports nutrition, L-Arginine 2-oxopentanedioate is utilized as an exercise performance booster, potentially aiding in increased stamina and reduced fatigue during physical activities by supporting energy production through the Krebs cycle.
Used in Nutritional Supplements:
L-Arginine 2-oxopentanedioate is used as an ingredient in nutritional supplements designed to support overall health and well-being, particularly focusing on energy levels and athletic performance.
Used in Pharmaceutical Development:
In the pharmaceutical industry, L-Arginine 2-oxopentanedioate is used in the development of drugs aimed at improving circulation and athletic performance, capitalizing on its dual role in the synthesis of proteins and energy production.

InChI:InChI=1/2C6H14N4O2.C5H6O5.2H2O/c2*7-4(5(11)12)2-1-3-10-6(8)9;6-3(5(9)10)1-2-4(7)8;;/h2*4H,1-3,7H2,(H,11,12)(H4,8,9,10);1-2H2,(H,7,8)(H,9,10);2*1H2

Upstream product

• 74-79-3 L-arginine 
• 42964-50-1 dimethyl 2,2-dichloro-1,5-pentanedioate 

Relevant articles and documents

Process for preparation of alpha-ketoglutaric acid

A process for preparation of α-ketoglutaric acid, which is adapted for preparing L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: (a) reacting methyl dichloroacetate and acrylic acid methyl ester with sodium methoxide to obtain dimethyl 2,2-dichloroglutarate; (b) reacting the dimethyl 2,2-dichloroglutarate from step (a) with hydroxide solution to obtain crude α-ketoglutaratic acid aqueous solution; (c) purifying the crude α-ketoglutaratic acid aqueous solution to obtain purified α-ketoglutaratic acid aqueous solution; and (d) adjusting a concentration of the purified α-ketoglutaratic acid aqueous solution by adding water, thereby a yield of the purified α-ketoglutaratic acid aqueous solution is approximately 75%. While avoiding the use of massive organic solvents, the process of the present invention has a remarkable high yield to realize mass production with low manufacturing cost and shortened production time.

Process for preparation of L-Arginine alpha-ketoglutarate 1:1 and 2:1

A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3?4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5?7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.