52596-80-2

Upstream product

• 1573171-19-3 C₂₀H₂₂BNO₃ 
• 74-88-4 methyl iodide 
• 835-71-2 2-(4-methylphenyl)-1,3-benzoxazole 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-94-5 p-Toluic acid 

Downstream Products

• 71943-82-3 2-(4-{4-[1-(4-chloro-phenyl)-1H-pyrazol-3-yl]-styryl}-phenyl)-7-methyl-benzooxazole 
• 71943-74-3 7-methyl-2-{4-[4-(1-phenyl-1H-pyrazol-3-yl)-styryl]-phenyl}-benzooxazole 
• 65146-30-7 2-{4-[4-(4-chloro-5-methoxy-[1,2,3]triazol-2-yl)-styryl]-phenyl}-7-methyl-benzooxazole 
• 71944-03-1 2-{4-[4-(1,5-diphenyl-1H-pyrazol-3-yl)-styryl]-phenyl}-7-methyl-benzooxazole 
• 65146-18-1 2-{4-[4-(4-methoxy-[1,2,3]triazol-2-yl)-styryl]-phenyl}-7-methyl-benzooxazole 
• 59098-90-7 7-methyl-2-{4-[4-(2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-benzooxazole 
• 59099-31-9 7-methyl-2-{4-[4-(4-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-benzooxazole 
• 65204-26-4 2-{4-[4-(4,5-diphenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-7-methyl-benzooxazole 
• 65204-16-2 2-{4-[4-(4-chloro-5-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-7-methyl-benzooxazole 
• 65203-92-1 2-{4-[4-(5-chloro-2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-7-methyl-benzooxazole 

Relevant academic research and scientific papers

Palladium-Catalyzed Methylation of Aryl, Heteroaryl, and Vinyl Boronate Esters

A method for the direct methylation of aryl, heteroaryl, and vinyl boronate esters is reported, involving the reaction of iodomethane with aryl-, heteroaryl-, and vinylboronate esters catalyzed by palladium and PtBu2Me. This transformation occurs with a remarkably broad scope and is suitable for late-stage derivatization of biologically active compounds via the boronate esters. The unique capabilities of this method are demonstrated by combining carbon-boron bond-forming reactions with palladium-catalyzed methylation in a tandem transformation.

Eine einfache Methode zur Herstellung von Benzoxazolen

The preparation of benzoxazoles by a facile one-pot reaction is reported.The reaction of carboxylic acids with 2-chloro-N-methyl-Δ1-pyrrolinium chloride in an excess of N-methyl-2-pyrrolidone afforded carboxylic acid chlorides which were converted subsequently to their 2-hydroxyanilides by addition of 2-aminophenols.Cyclization of the 2-hydroxy-anilides at elevated temperatures furnished the benzoxazoles in high yield and purity.