52597-70-3Relevant academic research and scientific papers
Application of E1cB Elimination in Asymmetric Organocatalytic Cascade Reactions to Construct Polyheterocyclic Compounds
You, Zhi-Hao,Chen, Ying-Han,Tang, Yu,Liu, Yan-Kai
, p. 8358 - 8363 (2019)
By introducing a carbon functionality at 2-position of chromane, the formal asymmetric functionalization of the 3-position of 2-substituted chromane has been realized via a highly chemo-, regio-, and stereoselective organocatalytic cascade reaction in a sequential one-pot manner involving an E1cB mechanism governed ring-opening process. Critical to our success was the design of a chiral dipeptide-based bifunctional acid-base organocatalyst, which exhibited high catalytic activity at low catalyst loading (1-0.1 mol %), leading to biologically interesting polyheterocyclic compounds.
4,6-Diacetylresorcinol in heterocyclic synthesis Part II: Synthesis of some novel 4,6-bis(azolyl/azinyl/ azepinyl)resorcinols
Assiri, Mohammed A.,Ali, Tarik E.,Ibrahim, Magdy A.,El-Amin,Yahia
, p. 114 - 125 (2019/06/24)
– A series of new 4,6-bis(azolyl/azinyl/azepinyl)resorcinols was synthesized in a combinatorial manner besides, (2E,2'E)-4,6-bis[3-(aminophenyl-substituted)prop-2-en-1-oxo-1-yl]resorcinols were also obtained. Heterocyclization of (2E,2'E)-4,6-bis[3-(dimethylamino)prop-2-en-1-oxo-1-yl]resorcinol (2) with nitrogen-containing binucleophiles afforded the target compounds. All the newly synthesized compounds were characterized by spectral tools.
