52601-83-9

Upstream product

• 52601-81-7 4-Methyl-N,N-bis<2-(methylsulfonyloxy)ethyl>benzolsulfonamid 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 7146-67-0 N-tosyldiethanolamine 

Downstream Products

• 133816-13-4 N,N-Bis<2-<(2S,5R)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-2-pyrazinyl>ethyl>-4-methylphenylsulfonamide 
• 133816-12-3 N,N-Bis<2-<(2S,5R)-2,5-dihydro-5-isopropyl-3,6-dimethoxy-2-methyl-2-pyrazinyl>ethyl>-4-methylphenylsulfonamide 
• 220961-17-1 4-methyl-N,N-bis-[2-(2-oxo-benzothiazol-3-yl)-ethyl]-benzenesulfonamide 
• 220961-18-2 N,N-bis-[2-(2-mercapto-phenylamino)-ethyl]-4-methyl-benzenesulfonamide 
• 133816-16-7 N,N-Bis<(3S)-3-amino-4-tert-butyldiphenylsilyl-3-methylbutyl>-4-methylphenylsulfonamide 
• 133816-14-5 N,N-Bis<(3S)-3-amino-3-methoxycarbonylbutyl>-4-methylphenylsulfonamide 
• 133816-15-6 N,N-Bis<(3S)-3-amino-4-hydroxy-3-methylbutyl>-4-methylphenylsulfonamide 
• 74568-92-6 N,N-bis(3-amino-3,3-diallylpropyl)-4-methylbenzosulfonamide dihydrochloride 
• 74568-90-4 4,4'-<<(4-Methylphenyl)sulfonyl>imino>bis<2,2-diallylbutansaeureazid> 
• 74568-93-7 N,N-Bis(3-amino-3,3-dimethylpropyl)-4-methylbenzolsulfonamid Dihydrochlorid 
• 74568-88-0 4,4'-<<(4-Methylphenyl)sulfonyl>imino>bis<2,2-diallylbutansaeurechlorid> 
• 74568-86-8 4,4'-<<(4-Methylphenyl)sulfonyl>imino>bis<2,2-diallylbutansaeure> 
• 343858-72-0 N,N-Bis-(3-allyl-3-isocyanato-hex-5-enyl)-4-methyl-benzenesulfonamide 
• 74568-91-5 4,4'-<<(4-Methylphenyl)sulfonyl>imino>bis<2,2-dimethylbutansaeureazid> 

Relevant academic research and scientific papers

New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.

Transition metal complexes with sulfur ligands, 135 [(+)] - Electron- rich Fe and Ru complexes with the new trisamine dithiolate ligand 'N3H3S2'-H2-bis(2-mercaptophenylamino)diethylamine]

In order to obtain iron and ruthenium complexes which are analogous to [M(L)('NHS4')] and [M(L)('N2H2S3')] complexes ['NHS4'2- = 2,2'-bis(2- mercaptophenylthio)diethylamine(2-), 'N2H2S3'2- = 2,2'-bis(2- mercaptophenylamino)diethylsulfide(2-)] but have electron-richer metal centers, the new pentadentate amine thiolate ligand 'N3H3S2'-H2 [ = 2,2'bis(2-mercaptophenylamino)diethylamine] (4) was synthesized. The dianion 'N3H3S2'2- reacted with Fe(II) salts to give high-spin [Fe('N3H3S2')] (5) [μ(eff) (293 K) = 3.94 μ(B)], which yielded diamagnetic [Fe(CO)('N3H3S2')] (6) upon reaction with CO. Complex 6 exhibits a low- frequency v(CO) band (1934 cm-1 in THF) indicating an electron-rich Fe center and a strong Fe-CO bond. In spite of this, 6 readily dissociated in solution to 5 and CO. The reaction of [RuCl2(PPh3)3] with 'N3H3S2'2- yielded [Ru(PPh3)('N3H3S2')] (7), which proved inert with respect to PPh3 substitution but could be methylated at the thiolate donors. The resulting [Ru(PPh3)('N3H3S2'-Me2)]I2 (8) proved as inert towards substitution as 7. Complex 8 could reversibly be deprotonated to give [Ru(PPh3)('N3'-H2S2'-Me2)]I (11), in the course of which the [RuPN3S2] cores rearrange from C(S) to C1 symmetry. Reversible protonation/deprotonation was also found with [Ru(NO)('N3'-H2S2')] (9) which formed from [RuCl3(NO)(PPh3)2] and 'N3H3S2'2- in the presence of one additional equivalent of LiOMe. Protonation of 9 with HBF4 gave [Ru(NO)('N3H3S2')]BF4 (10). The NMR spectra and the X-ray structure analysis of 8 proved that the [RuPN3S2] cores of 7 and 8 exhibit a Cs- symmetrical meso structure. In all other complexes, however, the [MLN3S2] cores exhibit a C1-symmetrical structure. It results from the fac-mer coordination mode of the 'N3H3S2'2- ligand and favors the planarization of amide donors when NH functions are reversibly deprotonated.

Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine

Levorotatory and dextrorotatory enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine of the formula STR1 their preparation and use for the preparation of substantially optically pure enantiomers of 1-[(4-chlorophenyl)phenylmethyl]piperazine, which are themselves valuable intermediate products for the preparation of optically active therapeutic compounds having a very high degree of optical purity.

Synthesis of Symmetrically Substituted Bicyclic Guanidines

The symmetrically 2,2,8,8-tetraalkylsubstituted bicyclic guanidines 14a and b are prepared stereoselectively via construction of the open-chain triamines 11a and b and subsequent cyclisation.A one-pot reaction gives the unsubstituted guanidine 14c in high