52602-94-5

Usage

InChI:InChI=1/C15H15N3O5S.ClH/c1-8-7-24-14-11(16)13(19)17(14)12(8)15(20)23-6-9-2-4-10(5-3-9)18(21)22;/h2-5,11,14H,6-7,16H2,1H3;1H/t11-,14-;/m1./s1

Upstream product

• 101-02-0 triphenyl phosphite 
• 34104-27-3 3-Methyl-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,p-nitrobenzyl ester 
• 19909-81-0 tris(p-methoxyphenyl)phosphite 
• 28974-31-4 3-methyl-2-(4-nitro-benzyloxy-carbonyl)-8-oxo-7-phenoxyacetamido-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene 
• 513-35-9 2-methyl-but-2-ene 
• 5679-61-8 tris(p-chlorophenyl)phosphite 

Relevant academic research and scientific papers

Halogenating reagents

Novel halogenating agents are derived from triaryl phosphites and chlorine or bromine. They are useful in converting 7-acylamino-3-hydroxy-3-cephem compounds to 7-acylamino-3-halo-3-cephems and the corresponding C-7 imino halide cephem derivatives.

Process for preparation of penicillin and cephalosporin imino halides

Penicillin and cephalosporin imino halides are prepared by reacting of 6-acylaminopenicillins or 7-acylamino cephalosporins with a novel chlorinating compound derived from a triaryl phosphite and chlorine or bromine. The imino halide products are intermediates in the preparation of antibiotic compounds.

Method of stabilization of kinetically controlled triaryl phosphite-halogen compounds

The kinetically controlled products of the reaction of triaryl phosphites and bromine or chlorine are stabilized by the presence of tertiary amine bases or halide complexing reagents. The stabilized halogenating reagents are useful in the preparation of 3

Process for cleaving an imido side chain from penicillins and cephalosporins

The amic acid group of a 7-(amic acid) cephalosporin or 6-(amic acid) penicillin is cleaved by dehydration to the corresponding novel 7-isoimidocephalosporin or 6-isoimido-penicillin, and cleavage of the 7-isoimidocephalosporin or 6-isoimidopenicillin to the corresponding 7-aminocephalosporin or 6-aminopenicillin or to a corresponding 7-acylamidocephalosporin or 6-acylamidopenicillin.