52616-38-3Relevant academic research and scientific papers
Memory of chirality of tertiary aromatic amide: Application to the asymmetric synthesis of (S)-α-methylDOPA
Mai, Thi Thoa,Viswambharan, Baby,Gori, Didier,Kouklovsky, Cyrille,Alezra, Valerie
, p. 8797 - 8801,5 (2020/09/15)
We describe an original asymmetric synthesis of (S)-α-methylDOPA proceeding by the concept of memory of chirality, the only source of chirality being the starting d-alanine. The initial chirality of the amino acid is temporarily transferred to a dynamic axial chirality of a tertiary aromatic amide. The (S)-α-methylDOPA hydrochloride is obtained after four steps with 98% ee.
