526197-35-3Relevant academic research and scientific papers
Synthesis of 3,3′-bi-1,2,4-Triazolo[4,5-a]-benzimidazole, 5,5′-bi-1,3,4-Thiadiazole, and Thiazolo[3,2-a]benzimidazole Derivatives
Dawood, Kamal M.,Raslan, Mohamed A.,Farag, Ahmad M.
, p. 4079 - 4086 (2003)
A series of novel 3,3′-bi-1,2,4-triazolo[4,5-a]benzimidazole and thiazolo[3,2-a]-benzimidazole derivatives were synthesized via the reaction of bis-hydrazonoyl chlorides with 2-methylthiobenzimidazole and with benzimidazol-2-thiol, respectively. A direct synthesis of 5,5′ -bi-1,3,4-thiadiazole and 4,5-bis-phenylhydrazono-2,3,4,5-tetrahydrothiazole derivatives is also described.
Regioselectivity in reactions of bis-hydrazonoyl halides with some bifunctional heterocycles
Shawali, Ahmad S.,Abdallah, Magda A.,Zayed, Mohie E. M.
, p. 1035 - 1040 (2007/10/03)
Bis-hydrazonoyl chloride 1 reacts regioselectively with 3-mercapto-1,2,4-triazole 2a, 2,3-dihydro-3-thioxo-1,2,4-triazin-5(4H)-one 2b and 2-mercaptobenzimidazole 2c to give the hitherto unknown annelated 2,3-bis-(phenylhydrazono)thiazoles 6a-c, respectively. Reactions of 1 with the methylthio derivatives of such heterocycles afforded the annelated 3,3′-bis-(1,2,4-triazoles) 11a-c, respectively. Similar reaction of 1 with 2-phenylamino-4(3H)-pyrimidinones 4 gave 2,3-bis(phenylhydrazono)imidazo[1,2-a] pyrimidin-5(1H)-ones 16. Oxidation of 6c yielded the corresponding bis(phenylazo) derivative 15. The regiochemistry of the studied reactions is discussed.
