5262-74-8Relevant academic research and scientific papers
Novel aminoalcohol derivatives bearing 4-phenylphenol as antischistosomal drugs
Duan, Li-Ping,Xue, Jian,Tao, Yi,Zhang, Hao-Bing
scheme or table, p. 694 - 697 (2012/09/22)
There is a need to develop new antischistosomal compounds when the only available therapeutic agents praziquantel large-scale used in the world. A series of novel aminoalcohol derivatives bearing 4-phenylphenol moiety were designed and synthesized. The structures of all the newly synthesized compounds were identified by elemental analysis, 1H-NMR, 13C-NMR and LC-MS. Their biological activities were evaluated against Schistosoma japonicum in mice by an oral route. Among these compounds, in vivo, at concentrations 400mg/kg of mouse, compound 1-(biphenyl-4′-yloxy)-3-(1′-(3′, 4′-difluorophenyl)ethylamino)propan-2-ol (3j) produced the highest activity with 93.0% deparasitization. These compounds may find usefulness in the discovery and development of new antischistosomal drugs.
Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes
Peukert, Stefan,Jacobsen, Eric N.
, p. 1245 - 1248 (2008/02/09)
(matrix presented) The kinetic resolution of epoxides with phenols catalyzed by a polymer-supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries. The corresponding 1-aryloxy-2-alcohols are obtained i
