5262-84-0

Usage

Explanation

The molecular formula representing the number of carbon (C), hydrogen (H), nitrogen (N), and oxygen (O) atoms in the compound.

Explanation

The compound is derived from two parent structures, piperidine (a heterocyclic amine) and naphthalene (a polycyclic aromatic hydrocarbon).

Explanation

It belongs to a class of drugs that stimulate beta-adrenergic receptors, which are involved in various physiological processes, including relaxation of smooth muscles.

Explanation

The compound has been studied for its potential use in treating respiratory conditions by improving airflow and reducing inflammation.

Explanation

The compound works by activating specific receptors in the respiratory system, leading to bronchodilation (widening of the airways) and improved airflow.

Explanation

Further studies are being conducted to understand the compound's effectiveness, safety, and possible side effects in treating various conditions, including respiratory diseases.

Derivatives

Piperidine and naphthalene

Classification

Beta-adrenergic agonist

Pharmaceutical applications

Potential treatment for asthma and chronic obstructive pulmonary disease (COPD)

Mechanism of action

Stimulating beta-adrenergic receptors in the smooth muscle of the airways

Ongoing research

Exploring the full therapeutic potential

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 30200-48-7 N-desisopropylpropranolol 
• 110-89-4 piperidine 
• 90-15-3 α-naphthol 
• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 

Relevant academic research and scientific papers

Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells

The ligand-sensing transcription factor tailless homologue (TLX, NR2E1) is an essential regulator of neuronal stem cell homeostasis with appealing therapeutic potential in neurodegenerative diseases and central nervous system tumors. However, knowledge on TLX ligands is scarce, providing an obstacle to target validation and medicinal chemistry. To discover TLX ligands, we have profiled a drug fragment collection for TLX modulation and identified several structurally diverse agonists and inverse agonists of the nuclear receptor. Propranolol evolved as the strongest TLX agonist and promoted TLX-regulated gene expression in human glioblastoma cells. Structure-activity relationship elucidation of propranolol as a TLX ligand yielded a structurally related negative control compound. In functional cellular experiments, we observed an ability of propranolol to counteract glioblastoma cell proliferation and migration, while the negative control had no effect. Our results provide a collection of TLX modulators as initial chemical tools and set of lead compounds and support therapeutic potential of TLX modulation in glioblastoma.

Aryloxy propyldiamines

Disclosed herein are compounds of the formula STR1 in which Ar is l-naphthyl; R1 and R2 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R1 and R2 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidine, morpholine and 4-(lower alkyl)-1-piperazinyl; and R3 and R4 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R3 and R4 together with the nitrogen to which they are joined represent a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl; or a therapeutically acceptable acid addition salt thereof. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof

Disclosed herein are compounds of the formula STR1 in which Ar is phenyl or 1-naphthyl; R1 is hydrogen or lower alkyl; and R2 and R3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.