526207-97-6Relevant academic research and scientific papers
α,β-Diketo nitriles as dielectrophiles. Formation of heterocyclic derivatives of amino acids
Wasserman, Harry H.,Long, Yun Oliver,Parr, Jonathan
, p. 361 - 363 (2003)
The reactions of mono Boc-protected amino monocarboxylic acids with phosphoranylideneacetonitrile yield ylido nitriles which on ozonolysis at low temperature form labile α,β-diketo nitriles. These derivatives may be used in situ for reaction with diamines or related dinucleophiles to yield hetero derivatives of interest as unnatural amino acid building blocks.
Cyclizations of α-keto ester modified aspartic acids in peptides
Seufert, Wolfgang,Fleury, Antoine,Giese, Bernd
, p. 1774 - 1776 (2006)
Aspartic acid peptides with α-keto ester modification can cyclize to form γ-lactam derivatives. This reaction represents an easy access to conformationally restricted peptidomimetics. Georg Thieme Verlag Stuttgart.
