526223-02-9

Upstream product

• 526222-96-8 (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7,8-dicarboxylic acid 7-benzyl ester 8-tert-butyl ester 
• 526223-00-7 (2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 
• 526222-98-0 (5S,8S)-2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-1,3,7,8-tetracarboxylic acid 7-benzyl ester 1,3,8-tri-tert-butyl ester 
• 526222-99-1 (3S,5S)-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)-3-aminopyrrolidine-3-carboxylic acid 
• 526223-01-8 (2S,4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester 

Downstream Products

• 526223-06-3 C₂₉H₃₈N₈O₁₀ 
• 773894-73-8 (2S,3aR,6R,7aR)-2-((3S,5S)-5-Carbamoyl-3-methoxycarbonyl-pyrrolidin-3-ylcarbamoyl)-6-{[(3S,5S,8S)-8-(4-hydroxy-benzyl)-7,10-dioxo-2,6,9-triaza-spiro[4.5]decane-3-carbonyl]-amino}-octahydro-indole-6-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Bis (amino acid) molecular scaffolds

The present invention provides molecular building blocks of rigid bis(amino acids). The molecular building blocks can be linked together through the formation of rigid diketopiperazine rings, to provide the desired three dimensional structure. Also provided is method of synthesizing macromolecules from the bis (amino acid) building blocks.

The synthesis of functionalized nanoscale molecular rods of defined length

We report a synthetic approach to spiro-ladder oligomers of defined length and structure that form water-soluble molecular rods. We describe the synthesis of a chiral molecular building block 1 and its assembly on solid support to form flexible chains that were then rigidified by the parallel formation of several diketopiperazine rings. Two molecular rods approximately 15 and 25 A in length were synthesized containing three and five monomers, respectively. The molecular rods were easily functionalized on both ends and were shown to have high water solubility, making them compatible with biological buffers. These molecules may find use as scaffolds for the display of ligands in chemical-biology applications and as spacers and construction materials for nanoscience applications. Copyright