52646-45-4

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 153-61-7 cephalothin 
• 23304-25-8 p-methoxyphenyldiazomethane 
• 16361-79-8 (6R)-3-acetoxymethyl-7t-amino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 39098-97-0 2-thienylacetic acid chloride 
• 52154-65-1 (6R)-3-acetoxymethyl-7t-(4-nitro-benzylideneamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 16361-79-8 p-methoxybenzyl d,l-7β-amino-3-acetoxymethyl-3-cephem-4-carboxylate 
• 175552-79-1 C₁₁H₁₄N₂O₄ 
• 35573-36-5 N-(4-methoxyphenylmethyl)carbamic acid ethyl ester 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 16361-79-8 (6R)-3-acetoxymethyl-7t-amino-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 52154-65-1 (6R)-3-acetoxymethyl-7t-(4-nitro-benzylideneamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 153-61-7 (6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 50919-03-4 (6R)-3-acetoxymethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 1609080-24-1 C₁₇H₁₉ClN₂O₄S*C₇H₈O₃S 
• 1609070-71-4 C₂₃H₂₃ClN₂O₅S₂ 
• 1609070-69-0 C₂₃H₂₃ClN₂O₅S₂ 
• 1609070-68-9 C₂₃H₂₂N₂O₅S₂ 
• 153-61-7 cephalothin 

Relevant academic research and scientific papers

Mild preparation of cephalosporin allyl and p-methoxybenzyl esters using diazoalkanes

Vinyl or p-methoxyphenyldiazomethane reacts rapidly with cephalosporins in ether/methylene chloride cosolvent to give the C-9 allyl and p-methoxybenzyl esters, respectively, in good yields, with no isomerization of the double bond to Δ-2.

Process for preparing cephalosporin esters in the presence of liquid sulfur dioxide

A process for preparing a cephalosporin ester which comprises subjecting an organic halide or an alcohol to reaction with a cephalosporin acid, a cephalosporin acid halide or a salt thereof in the presence of liquid sulfur dioxide.

Cephalosporin compounds

Novel 7-azido-3-cephem compounds are prepared via α-amino-phosphonoacetate esters. The cephem compounds are intermediates for the preparation of novel and known useful antibiotic cephalosporins.