52648-67-6Relevant articles and documents
InBr3-catalyzed Friedel-Crafts addition of indoles to chiral aromatic epoxides: A facile route to enantiopure indolyl derivatives
Bandini, Marco,Cozzi, Pier Giorgio,Melchiorre, Paolo,Umani-Ronchi, Achille
, p. 5386 - 5389 (2002)
Aromatic optically active epoxides can be opened in a regioselective and clean way with indoles in the presence of catalytic amount of InBr3 (1 mol %). The reaction takes place with a SN2 pathway affording the 2-aryl-2-(3′-indolyl)-ethan-l-ols with excellent enantioselectivity (ee up to 99%).
Regio- and enantioselective Friedel-Crafts reactions of indoles to epoxides catalyzed by graphene oxide: A green approach
Acocella, Maria Rosaria,Mauro, Marco,Guerra, Gaetano
, p. 3279 - 3283 (2015/02/03)
Graphene oxide efficiently promotes high regio- and enantioselective ring opening reactions of aromatic epoxides by indoles addition, in solvent- and metal-free conditions. The Friedel-Crafts products were obtained with enantioselectivity up to 99% ee. Th