52648-88-1

Upstream product

• 40861-85-6 3-Acetyl-5-ethoxycarbonyl-1,2,4-trimethylpyrrole 
• 108-86-1 bromobenzene 
• 136558-76-4 3-Acetyl-5-carboxy-1,2,4-trimethylpyrrole 
• 2386-27-8 benzyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate 
• 157578-89-7 benzyl 4-acetyl-1,3,5-trimethyl-pyrrole-2-carboxylate 
• 2386-25-6 2,4-dimethyl-3-acetylpyrrole 
• 74-88-4 methyl iodide 
• 2386-26-7 ethyl 4-acetyl-3,5-dimethylpyrrole-2-carboxylate 

Downstream Products

• 105256-98-2 3-Ethyl-1,2,4-trimethylpyrrole-5-carboxaldehyde 
• 136558-73-1 3-Ethynyl-1,2,4-trimethylpyrrole-5-carboxaldehyde 
• 136558-78-6 3-Acetyl-1,2,4-trimethylpyrrole-5-carboxaldehyde 
• 136558-77-5 3-(1'-Chlorovinyl)-1,2,4-trimethylpyrrole-5-carboxaldehyde 

Relevant academic research and scientific papers

Decarboxylative arylation of substituted pyrroles N -protected with 2-(trimethylsilyl)ethoxymethyl (SEM)

Palladium-catalyzed decarboxylative arylation is reported using pyrroles N-protected with the 2-(trimethylsilyl)ethoxymethyl (SEM) group and featuring 2-, 3-, and 4-substituents about the pyrrolic framework. In contrast to N-protected pyrroles previously

Preparation method and purpose of pyrrolone BRD4 protein inhibitor

The invention relates to the field of medicinal chemistry, in particular to pyrrolone derivatives, a preparation method of the pyrrolone derivatives, a pharmaceutical composition containing the compounds and medical purposes of the pharmaceutical composition, particularly an antitumor purpose of the pharmaceutical composition as a BRD4 protein inhibitor.

Synthesis of Functionalized N-Methylpyrroles

The preparation of some new N-methylpyrroles is shown.These heterocyclic compounds were used to synthesize polyenic substances with polysubstituted pyrrole rings.