52665-49-3

Basic information

• Product Name: FURAN-3-SULFONYL CHLORIDE
• Synonyms: FURAN-3-SULFONYL CHLORIDE;FURAN-3-SULPHONYL CHLORIDE;Furan-3-sulphonyl chloride 97%;3-(Chlorosulphonyl)furan;3-furansulfonylchloride;Furan-3-sulphonylchloride97%
• CAS NO: 52665-49-3
• Molecular Formula: C₄H₃ClO₃S
• Molecular Weight: 166.58
• Mol File: 52665-49-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 226.128 °C at 760 mmHg
• Flash Point: 90.56 °C
• Appearance: /
• Density: 1.529g/cm³
• Vapor Pressure: 0.125mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: FURAN-3-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FURAN-3-SULFONYL CHLORIDE(52665-49-3)
• EPA Substance Registry System: FURAN-3-SULFONYL CHLORIDE(52665-49-3)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 52665-49-3(Hazardous Substances Data)

Usage

General Description

Furan-3-sulfonyl chloride, also known as 3-sulfonyl chloride furan, is a chemical compound with the molecular formula C4H3ClO2S. It is a colorless to light yellow liquid that is primarily used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is a highly reactive compound that is capable of forming covalent bonds with a variety of organic compounds, and it is widely used as an intermediate in the production of sulfonamides, which are important pharmacological agents. Furan-3-sulfonyl chloride is also known for its strong sulfonating ability, making it a valuable tool in the modification of organic molecules for various industrial applications. However, it should be handled with caution, as it is corrosive and can cause severe skin and eye irritation.

InChI:InChI=1/C4H3ClO3S/c5-9(6,7)4-1-2-8-3-4/h1-3H

Upstream product

• 22037-28-1 3-bromofurane 

Downstream Products

• 1269500-24-4 C₁₉H₂₅N₃O₆S 
• 1380228-95-4 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)furan-3-sulfonamide 
• 1195769-75-5 1,1-dimethylethyl 4-(5-(2-chloro-4-pyrimidinyl)-4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-1-piperidinecarboxylate 
• 1195769-67-5 1,1-dimethylethyl 4-(5-(2-chloro-4-pyrimidinyl)-4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-4-methyl-1-piperidinecarboxylate 
• 1195769-61-9 1,1-dimethylethyl [1-(5-(2-chloro-4-pyrimidinyl)-4-{2-fluoro-3-[(3-furanylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-1-methylethyl]carbamate 
• 1138036-36-8 2-(2-fluorophenyl)-1-(furan-3-ylsulfonyl)-1H-imidazole-4-carbaldehyde 
• 1141802-54-1 N-{4-[3-(1,2-O-isopropylidene-D-ribotetritol-1-yl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]phenyl}furan-3-sulfonamide 
• 1040279-97-7 N-(3-amino-8-chloro-1-phenyl-5,6-dihydrobenzo[f]quinazolin-9-yl)furan-3-sulfonamide 
• 909897-05-8 methyl 4-{[2-[(3-furylsulfonyl)amino]-5-(trifluoromethyl)phenoxy]methyl}benzoate 
• 1383745-20-7 C₁₂H₁₀ClFN₂O₄S 

Relevant articles and documents

SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE

The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.