5267-39-0

Basic information

• Product Name: 4-Chlorobenzhydrylamine hydrochloride
• Synonyms: AURORA KA-7576;(4-CHLOROPHENYL)PHENYLMETHYLAMINE;4-CHLOROBENZHYDRYLAMINE;4-CHLOROBENZHYDRYLAMINE HYDROCHLORIDE, 9 8%;(4-CHLOROPHENY)PHENYLMETHYLAMINE;(4-CHLOROPHENY)PHENYLMETHYLAMINE HYDROCHLORIDE;4-Chloro-α-phenylbenzenemethanamine;(4-chlorophenyl)(phenyl)MethanaMine hydrochloride
• CAS NO: 5267-39-0
• Molecular Formula: C₁₃H₁₂ClN*ClH
• Molecular Weight: 217.69
• EINECS: 226-085-6
• Product Categories: Amine Salts;Nitrogen Compounds;Organic Building Blocks
• Mol File: 5267-39-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 300-305 °C (dec.)(lit.)
• Boiling Point: 336.8 °C at 760 mmHg
• Flash Point: 199.3 °C
• Appearance: /
• Vapor Pressure: 0.000109mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-Chlorobenzhydrylamine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chlorobenzhydrylamine hydrochloride(5267-39-0)
• EPA Substance Registry System: 4-Chlorobenzhydrylamine hydrochloride(5267-39-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 5267-39-0(Hazardous Substances Data)

Usage

General Description

4-Chlorobenzhydrylamine hydrochloride is a chemical compound composed of a benzhydrylamine moiety with a chlorine atom substituted on the benzene ring, and a hydrochloride salt. It is a white crystalline solid that is commonly used as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. It is also known for its use as a precursor in the synthesis of various psychoactive substances. The compound is mainly utilized for its nucleophilic properties, making it a valuable tool in the pharmaceutical and chemical industries for the development of new drugs and materials. Additionally, it is of interest to researchers and scientists due to its potential applications in medicinal chemistry and drug discovery.

InChI:InChI=1/C13H12ClN.ClH/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10;/h1-9,13H,15H2;1H

Upstream product

• 100-46-9 benzylamine 
• 106-39-8 bromochlorobenzene 
• 108-86-1 bromobenzene 
• 56542-87-1 1-(4-chlorophenyl)-N-(diphenylmethylene)methanamine 
• 7699-79-8 benzhydrylidene-benzyl-amine 

Downstream Products

• 83375-05-7 p-chlorobenzhydrylurea 
• 1009371-00-9 ({[(4-chlorophenyl)phenylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester 
• 21333-49-3 4-chlorobenzhydryl isothiocyanate 
• 1227753-26-5 C₂₈H₃₇ClN₂O₂ 
• 451503-28-9 (α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 
• 451503-28-9 (α¹S)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 
• 160807-85-2 1,3-bis((4-chlorophenyl)(phenyl)methyl)urea 
• 1258949-42-6 ethyl ((4-chlorophenyl)(phenyl)methyl)carbamate 
• 1421837-29-7 N-((4-chlorophenyl)(phenyl)methyl)-2-(4-((3,5-dimethylisoxazol-4-yl)methylthio)phenyl)acetamide 
• 1421837-25-3 N-((4-chlorophenyl)(phenyl)methyl)-2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-2-methylpropanamide 
• 1421837-28-6 N-((4-chlorophenyl)(phenyl)methyl)-2-(5-((3,5-dimethylisoxazol-4-yl)methoxy)pyridin-2-yl)acetamide 
• 5267-40-3 N-[(4-chlorophenyl)(phenyl)methyl]acetamide 
• 49703-23-3 2-[(p-Chloro-α-phenylbenzyl)imino]hexahydroazepine hydrochloride 
• 221913-28-6 N-[Bis-(4-chlorophenyl)methyl]-4-(4,4,4-trifluoro-3-oxo-1-butyl)-phenoxyacetamide 

Relevant articles and documents

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed. This journal is the Partner Organisations 2014.

METHODS OF PREPARING SECONDARY CARBINAMINE COMPOUNDS WITH BORONIC ACIDS

The present application relates to novel methods for the preparation of secondary carbinamine compounds, particularly the preparation of secondary carbinamine compounds of the formula Ia, formula Ib or formula IV from aldehydes of the formula II and boronic acids of the formula III or formula V, in the presence of ammonia or an ammonia equivalent of the formula NH4+X-.