5267-39-0

Usage

Uses

Used in Organic Synthesis:
4-Chlorobenzhydrylamine hydrochloride is used as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions, facilitating the creation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-Chlorobenzhydrylamine hydrochloride is utilized as an intermediate, playing a critical role in the synthesis of various medicinal compounds, contributing to the development of new drugs.
Used in Medicinal Chemistry and Drug Discovery:
4-Chlorobenzhydrylamine hydrochloride is employed as a precursor in the synthesis of psychoactive substances, highlighting its importance in the exploration of novel therapeutic agents and advancing our understanding of psychopharmacology.
Used in Chemical Research:
4-Chlorobenzhydrylamine hydrochloride is used in research settings to study its nucleophilic properties and explore its potential applications in creating new materials and drug candidates, thereby expanding the horizons of chemical and pharmaceutical innovation.

InChI:InChI=1/C13H12ClN.ClH/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10;/h1-9,13H,15H2;1H

Upstream product

• 100-46-9 benzylamine 
• 106-39-8 bromochlorobenzene 
• 108-86-1 bromobenzene 
• 56542-87-1 1-(4-chlorophenyl)-N-(diphenylmethylene)methanamine 
• 7699-79-8 benzhydrylidene-benzyl-amine 

Downstream Products

• 49703-23-3 2-[(p-Chloro-α-phenylbenzyl)imino]hexahydroazepine hydrochloride 
• 1227753-26-5 C₂₈H₃₇ClN₂O₂ 
• 5267-40-3 N-[(4-chlorophenyl)(phenyl)methyl]acetamide 
• 1421837-25-3 N-((4-chlorophenyl)(phenyl)methyl)-2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)-2-methylpropanamide 
• 1421837-29-7 N-((4-chlorophenyl)(phenyl)methyl)-2-(4-((3,5-dimethylisoxazol-4-yl)methylthio)phenyl)acetamide 
• 83375-05-7 p-chlorobenzhydrylurea 
• 1258949-42-6 ethyl ((4-chlorophenyl)(phenyl)methyl)carbamate 
• 160807-85-2 1,3-bis((4-chlorophenyl)(phenyl)methyl)urea 
• 1421837-28-6 N-((4-chlorophenyl)(phenyl)methyl)-2-(5-((3,5-dimethylisoxazol-4-yl)methoxy)pyridin-2-yl)acetamide 
• 451503-28-9 (α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 
• 451503-28-9 (α¹S)-4-chloro-α-phenyl-benzenemethanamine hydrochloride 
• 221913-28-6 N-[Bis-(4-chlorophenyl)methyl]-4-(4,4,4-trifluoro-3-oxo-1-butyl)-phenoxyacetamide 
• 21333-49-3 4-chlorobenzhydryl isothiocyanate 
• 1009371-00-9 ({[(4-chlorophenyl)phenylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions

Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed. This journal is the Partner Organisations 2014.

METHODS OF PREPARING PRIMARY, SECONDARY AND TERTIARY CARBINAMINE COMPOUNDS IN THE PRESENCE OF AMMONIA

The present application relates to novel methods for the preparation of primary, secondary and tertiary carbinamine compounds, particularly the preparation of compounds of formulae I, IV and VI, from a carbonyl compound of formula II in the presence of ammonia or an ammonium equivalent of the formula NH4+X-, by way of allylation, crotylation, arylation, reductive amination and catalytic hydrogenation.

METHODS OF PREPARING SECONDARY CARBINAMINE COMPOUNDS WITH BORONIC ACIDS

The present application relates to novel methods for the preparation of secondary carbinamine compounds, particularly the preparation of secondary carbinamine compounds of the formula Ia, formula Ib or formula IV from aldehydes of the formula II and boronic acids of the formula III or formula V, in the presence of ammonia or an ammonia equivalent of the formula NH4+X-.