5268-71-3

Usage

Molecular structure

Complex

Chemical class

Benzimidazole thiazole

Functional groups

Acetyl and methyl

Biological activities

Anti-inflammatory
Anticancer
Antimicrobial

Pharmaceutical industry use

Potential drug candidate

Unique structure

Allows potential interactions with various biological targets

Application

Medicinal chemistry research and development

Upstream product

• 118795-48-5 1-(3-Methyl-benzo[4,5]imidazo[2,1-b]thiazol-2-yl)-ethanone; compound with 1,3-dihydro-benzoimidazole-2-thione 

Downstream Products

• 5268-76-8 3-Methyl-2-(1-oximino-aethyl)-thiazolo<3,2-a>benzimidazol 
• 116578-09-7 (E)-3-(4-Dimethylamino-phenyl)-1-(3-methyl-benzo[4,5]imidazo[2,1-b]thiazol-2-yl)-propenone 
• 116577-90-3 (E)-1-(3-Methyl-benzo[4,5]imidazo[2,1-b]thiazol-2-yl)-3-phenyl-propenone 
• 116578-08-6 (E)-1-(3-Methyl-benzo[4,5]imidazo[2,1-b]thiazol-2-yl)-3-(4-nitro-phenyl)-propenone 

Relevant academic research and scientific papers

Fission of 1,2,4-Thiadiazol-3-ones by Triphenylphosphane: Triphenylphosphonio Thioimidazolates and Their Consecutive Reactions

Treatment of benzimidazothiadiazol-3(2H)-ones (1) and imidazothiadiazol-3(2H)-ones (17) with triphenylphosphan leads to the liberation of isocyanate and the formation of triphenylphosphonio-thiobenzimidazolat (4) and triphenylphosphonio-thioimidazolat (18), respectively. 2,4-Diphenyl-5-phenylimino-1,2,4-thiadiazol-3-one (23) is desulfurized with Ph3P and decomposed into phenyl isocyanate and diphenylcarbodiimide whereas the N-unsubstituted imino-thiadiazol-3-one (25) is attacked at the exocyclic imino group by Ph3P to give the N-phosphoranylidene thiourea (26).The structure of 4 can be rationalized as a dynamic system between polar and apolar valence isomeres.Reactions of 1 and 17 with cyanates, isocyanates, carbon disulfide, acetic anhydride, amines, benzyl chloride, grignard compounds, and CH acidic compounds are described.