52700-25-1

Basic information

• Product Name: 1-(4-METHOXYPHENYL)-2-PYRIDIN-3-YL-ETHANONE
• Synonyms: 1-(4-METHOXYPHENYL)-2-PYRIDIN-3-YL-ETHANONE
• CAS NO: 52700-25-1
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.25852
• Mol File: 52700-25-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 403.2 °C at 760 mmHg
• Flash Point: 197.7 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)-2-PYRIDIN-3-YL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)-2-PYRIDIN-3-YL-ETHANONE(52700-25-1)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)-2-PYRIDIN-3-YL-ETHANONE(52700-25-1)

Safety Data

• Hazardous Substances Data: 52700-25-1(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)-2-pyridin-3-yl-ethanone, also known as Mepyramine, is a chemical compound with the molecular formula C14H14N2O2. It is an antihistamine that acts as a histamine H1 receptor antagonist, meaning it blocks the action of histamine in the body. Mepyramine is commonly used in the treatment of allergic conditions such as hay fever, hives, and allergic conjunctivitis. It works by reducing the effects of histamine, a substance produced by the body as part of its natural defense mechanisms. Mepyramine is often found in over-the-counter medications and can be found in various forms such as tablets, capsules, and topical creams. It is important to use this chemical under the guidance of a healthcare professional to ensure its safe and effective use.

InChI:InChI=1/C14H13NO2/c1-17-13-6-4-12(5-7-13)14(16)9-11-3-2-8-15-10-11/h2-8,10H,9H2,1H3

Upstream product

• 1120-90-7 3-iodopyridine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 303162-29-0 (4-methoxyphenyl)(2-methylaziridin-1-yl)methanone 
• 108-99-6 3-Methylpyridine 
• 94-30-4 ethyl 4-methoxybenzoate 

Downstream Products

• 23826-71-3 3-(4-methoxybenzoyl)pyridine 
• 59-67-6 nicotinic acid 
• 100-09-4 4-methoxybenzoic acid 
• 114584-01-9 2-(3-pyridyl)-3-(4-methoxyphenyl)-6-methoxyindene 
• 114584-09-7 2-(3-pyridyl)-3-(4-hydroxyphenyl)-6-hydroxyindene 
• 97422-28-1 [4-(4-Methoxyphenyl)-5-(pyridin-3-yl)-1,3-thiazol-2-yl]amine 
• 114583-96-9 1-(4-methoxyphenyl)-2-(3-pyridyl)-3-(3-methoxyphenyl)-1-propanone 

Relevant articles and documents

Palladium-Catalyzed Direct α-C(sp3) Heteroarylation of Ketones under Microwave Irradiation

Heteroaryl compounds are valuable building blocks in medicinal chemistry and chemical industry. A palladium-catalyzed direct α-C(sp3) heteroarylation of ketones under microwave irradiation is developed and reported in this study. Under optimized condition

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors

A novel series of 4-phenyl-5-pyridyl-1,3-thiazole analogues possessing potent in vitro inhibitory activity against p38 mitogen-activated protein kinase and the release of tumor necrosis factor-α (TNF-α) from human monocytic THP-1 cells stimulated by lipopolysaccharide has been identified. Subsequent structure-activity relationship (SAR) studies and optimization for absorption, distribution, metabolism, and elimination (ADME) profiles led to the identification of compounds 7g and 10b as orally active lead candidates that block the in vivo production of proinflammatory cytokine (TNF-α). In pharmacokinetic studies, compound 10b showed good oral administration in mice and demonstrated significant in vivo anti-inflammatory activity in an anti-collagen monoclonal antibody-induced arthritis mouse model (minimum effective dose (MED)=30 mg/kg). Further elucidation of this class of compounds may provide novel anti-inflammatory agents, such as anti-rheumatoid arthritis drugs.

CONCOMITANT DRUGS

The present invention relates to a pharmaceutical agent containing one or more kinds of a p38 MAP kinase inhibitor and/or a TNF-α production inhibitor and one or more kinds of drugs selected from the group consisting of (1) a non-steroidal antiinflammator