52700-65-9

Basic information

• Product Name: N-(2-bromophenyl)-3-oxobutanamide
• Synonyms: N-(2-bromophenyl)-3-oxobutanamide;N-(2-BROMO-PHENYL)-3-OXO-BUTYRAMIDE;UKRORGSYN-BB BBV-057192;N-(2-bromophenyl)-3-oxobutanamide(SALTDATA: FREE);N-(2-bromophenyl)-3-keto-butyramide
• CAS NO: 52700-65-9
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.11
• Mol File: 52700-65-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 411°C at 760 mmHg
• Flash Point: 202.4°C
• Appearance: /
• Density: 1.516g/cm³
• Vapor Pressure: 5.75E-07mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: N-(2-bromophenyl)-3-oxobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-bromophenyl)-3-oxobutanamide(52700-65-9)
• EPA Substance Registry System: N-(2-bromophenyl)-3-oxobutanamide(52700-65-9)

Safety Data

• Hazardous Substances Data: 52700-65-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10BrNO2/c1-7(13)6-10(14)12-9-5-3-2-4-8(9)11/h2-5H,6H2,1H3,(H,12,14)

Upstream product

• 1694-31-1 tert-butyl acetoacetate 
• 615-36-1 2-bromoaniline 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 138201-50-0 N'-[2-(2-Bromo-phenylcarbamoyl)-1-methyl-eth-(E)-ylidene]-phosphorohydrazidic acid diphenyl ester 
• 1452145-33-3 C₂₇H₂₃Br₂N₃O₃ 
• 1452145-78-6 C₁₇H₁₇BrN₂O 
• 622383-91-9 N-(2-bromophenyl)-5-fluoro-1,3-dimethylpyrazole-4-carboxamide 
• 107670-24-6 (E)-4-(2-Bromo-phenylcarbamoyl)-2-cyano-3-methyl-but-2-enoic acid ethyl ester 

Relevant articles and documents

Phenothiazine and amide-ornamented novel nitrogen heterocyclic hybrids: synthesis, biological and molecular docking studies

The synthesis of novel hybrids, namely, phenothiazine and amide-ornamented nitrogen heterocycles (25-34) has been accomplished utilizing a multi-step synthetic protocol and the structures have been established based on physical and spectral techniques. Of these, the hybrids possessing meta-nitro (26), para-fluoro (28), meta- and para-methyl (31), ortho-bromo (33) and ortho- and para-dimethyl (34) phenyl carboxamide scaffolds exhibited superior anti-inflammatory profiles over the standard diclofenac sodium. A hybrid integrated with a para-fluorophenyl carboxamide moiety (28) showed the highest DPPH radical scavenging activity among the chemical entities synthesized. Furthermore, the results of anticancer evaluations implied that the hybrid tethered with a phenyl carboxamide structural unit (29) exerted superior activity when compared with other hybrids against the pancreatic cancer cells SW1990 and AsPC1. Molecular docking between the hybrid 29 and B-cell lymphoma 2 reflects its appreciable binding affinity (-8.84 kcal mol-1). The results revealed that these chemical entities can serve as potent biological agents and/or efficient intermediates for the construction of potent biological agents.

On the Knorr synthesis of 6-bromo-4-methylquinolin-2(1H)-one

In the course of our work on infectious diseases, we were led to prepare 6-bromo-2-chloro-4-methylquinoline as a starting material. Since surprisingly little has been reported in the literature, the two synthetic steps to this compound were investigated. The synthesis involves a condensation between -keto esters and 4-bromoaniline and the cyclization of the resulting anilides into 6-bromoquinolin-2(1H)-one, otherwise known as the Knorr reaction. The 1H NMR monitoring of the first step allowed us to optimize the conditions leading specifically to the anilide without the occurrence of the alternative crotonate. To illustrate the scope of our finding, few additional anilides featuring electron-attracting groups were prepared. The study of their cyclization revealed some unsuspected steric effect governing this second step. Aside from rectifying a few claims in this chemistry, this study led to a three-step preparation of 6-bromo-2-chloro-4-methylquinoline in 48% overall yield from 4-bromoaniline. Georg Thieme Verlag Stuttgart - New York.