52712-76-2 Usage
Description
Bunazosin hydrochloride is a selective αl-adrenergic antagonist related to
prazosin and useful in the treatment of hypertension.
Originator
Eisai (Japan)
Uses
Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.
Manufacturing Process
17.0 g of 2-chloro-4-amino-6,7-dimethoxyquinazoline and 18.2 g of Nformylhomopiperazine
are added to 170 ml of butanol and the whole is
refluxed with stirring for 3 h. After completion of the reaction, the mixture is
cooled, and the crystals thus precipitated are filtered out, washed with a small
quantity of ethanol and air-dried. 25.0 g of crude 2-homopiperazino-4-amino-
6,7-dimethoxyquinazoline are obtained.
A solution of 2-homopiperazino-4-amino-6,7-dimethoxyquinazoline in 60 ml of
acetone is added dropwise to a solution of 2-butylcarboxylic acid chloride in
acetone under stirring and ice-cooling. After completion of the addition, the
stirring is continued for additional 1 h to complete the reaction. The crystals
thus precipitated are filtered out and the 1-(4-amino-6,7-dimethoxy-2-
quinazolinyl)hexahydro-4-(1-oxobutyl)-1H-1,4-diazepine, melting point 280-
282°C (recrystallized from a mixture of methanol-ethanol) is obtained.
Brand name
DETANTOL
Therapeutic Function
Antihypertensive
Check Digit Verification of cas no
The CAS Registry Mumber 52712-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,1 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52712-76:
(7*5)+(6*2)+(5*7)+(4*1)+(3*2)+(2*7)+(1*6)=112
112 % 10 = 2
So 52712-76-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H27N5O3.ClH/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19;/h11-12H,4-10H2,1-3H3,(H2,20,21,22);1H
