52723-82-7

Basic information

• Product Name: 4-BROMO-5-FLUORO-2-METHYLANILINE
• Synonyms: 4-BROMO-5-FLUORO-2-METHYLANILINE;4-Bromo-5-fluoro-o-toluidine;4-bromo-5-fluoro-2-methylbenzenamine;Benzenamine, 4-bromo-5-fluoro-2-methyl-;Methyl-4-bromo-5-fluoroaniline
• CAS NO: 52723-82-7
• Molecular Formula: C₇H₇BrFN
• Molecular Weight: 204.04
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 52723-82-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 77-80°C
• Boiling Point: 245℃
• Flash Point: 102℃
• Appearance: /
• Density: 1.589
• Vapor Pressure: 0.029mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.73±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-5-FLUORO-2-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-5-FLUORO-2-METHYLANILINE(52723-82-7)
• EPA Substance Registry System: 4-BROMO-5-FLUORO-2-METHYLANILINE(52723-82-7)

Safety Data

• Hazardous Substances Data: 52723-82-7(Hazardous Substances Data)

Usage

Chemical Properties

Type of white solid

InChI:InChI=1/C7H7BrFN/c1-4-2-5(8)6(9)3-7(4)10/h2-3H,10H2,1H3

Upstream product

• 367-29-3 3-fluoro-6-methylaniline 
• 452-62-0 3-bromo-4-fluorotoluene 
• 948294-26-6 1-bromo-2-fluoro-5-methyl-4-nitrobenzene 

Downstream Products

• 861928-20-3 1-bromo-2-fluoro-4-iodo-5-methylbenzene 
• 633335-80-5 N-(4-bromo-5-fluoro-2-methylphenyl)acetamide 
• 1086836-99-8 4-Bromo-3-fluoro-6-methyl-2-nitroaniline 
• 948294-26-6 1-bromo-2-fluoro-5-methyl-4-nitrobenzene 
• 633335-81-6 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethan-1-one 
• 1613505-13-7 6-fluoro-5-(2-(trifluoromethyl)phenyl)-1H-indazole 
• 1613504-89-4 C₁₉H₁₆F₄N₂O 
• 1433881-01-6 (S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one 
• 1351167-83-3 (4-bromo-5-fluoro-2-methylphenyl)(methyl)sulfane 
• 1351166-10-3 (S)-1-(1-(5-ethylpyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one 
• 1351166-09-0 (S)-1-(1-(5-chloropyrazin-2-yl)piperidin-4-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one 
• 1351168-04-1 (S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one 
• 1351168-03-0 (S)-benzyl 4-(3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate 
• 1351166-69-2 (S)-1'-(5-ethylpyrimidin-2-yl)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-[1,4'-bipiperidin]-2-one 

Relevant articles and documents

Compounds and their use in treatment on hepatitis B

The invention provides compounds, a pharmaceutical composition containing the compounds and an application of the compounds. The compound is a compound shown in a formula (I) or a stereoisomer, a tautomer, nitric oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound shown in the formula (I). The compound provided by the invention can interfere with the shell assembly process of hepatitis B virus, thereby inhibiting hepatitis B virus replication. Moreover, the compound has good absorption, relatively high biological activity and availability and low toxicity, particularly has relatively strong stability in vivo, is not easy to decompose and has long drug effect time, so that an effect of treating hepatitis B is achieved and the compound has a goodapplication prospect.

NRF2 REGULATORS

The present invention relates to aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.