5273-90-5

Upstream product

• 5273-88-1 1-Allyl-2,3,4-trimethoxybenzene 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 5150-42-5 2,3-dimethoxyphenol 
• 54440-47-0 1-(2,3,4-trimethoxyphenyl)-1-propanol 

Relevant academic research and scientific papers

Synthesis, antiepileptic effects, and structure-activity relationships of α-asarone derivatives: In vitro and in vivo neuroprotective effect of selected derivatives

In the present study, we compared the antiepileptic effects of α-asarone derivatives to explore their structure-activity relationships using the PTZ-induced seizure model. Our research revealed that electron-donating methoxy groups in the 3,4,5-position on phenyl ring increased antiepileptic potency but the placement of other groups at different positions decreased activity. Besides, in allyl moiety, the optimal activity was reached with either an allyl or a 1-butenyl group in conjugation with the benzene ring. The compounds 5 and 19 exerted better neuroprotective effects against epilepsy in vitro (cell) and in vivo (mouse) models. This study provides valuable data for further exploration and application of these compounds as potential anti-seizure medicines.

Role of the methoxy group in product formation via TiCl 4 promoted 4-phenyldioxolane isomerizations

The product distribution obtained from the TiCl 4 initiated intramolecular isomerizations of 4-methoxyphenyl-and trimethoxyphenyldioxolanes at -78 °C, -30 °C and 0 °C provided insights into the important regiochemical role played by these groups in such Mukaiyama-type rearrangements through their resonance effects on the aryl ring of the dioxolanes. ARKAT USA, Inc.

Neutral ionic liquid [hmim]Br as a green reagent and solvent for the mild and efficient dehydration of benzyl alcohols into (E)-arylalkenes under microwave irradiation

A mild and efficient, ionic-liquid-assisted, green protocol for the dehydration of benzyl alcohols into the corresponding (E)-arylalkenes under microwave irradiation has been developed. The method utilizes a neutral and recyclable ionic liquid (1-hexyl-3-methylimidazolium bromide) as a reagent and solvent to cleanly provide a wide range of olefins without the need of harsh and expensive Bronsted/Lewis acids. The method was extended to the efficient conversion of acetylated/benzoylated derivatives of benzyl alcohol into their corresponding (E)-arylalkenes. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

An effective system to synthesize hypolipidemic active α-asarone and related methoxylated (E)-arylalkenes

Methoxylated (E)-arylalkenes (1a-1k) were prepared in two steps by an improved Grignard reaction comprising the reverse addition of alkylmagnesium bromide to benzaldehydes (2a-2k) in anhydrous ether and toluene into arylalkanols (3a-3k) in high yield, followed by dehydration with silica gel under microwave irradiation for 3-12 min, depending upon the substituents attached to the aromatic ring to afford hypolipidemic active α-asarone (1a) and related methoxylated (E)-arylalkenes (1b-1k).

Feeding-deterrent activity of α-asarone isomers against some stored Coleoptera

All isomers of α-asarone [(E)-4-prop-1-enyl-1,2,5-trimethoxybenzene] were tested for their feeding deterrent activity against adults of Sitophilus granarius and Tribolium confusum and larvae of Trogoderma granarium and Tribolium confusum. (E)-2-prop-1-eny

Synthesis and hypolipidemic and antiplatelet activities of α-asarone isomers in humans (in vitro), mice (in vivo), and rats (in vivo)

A series of α-asarone isomers was synthesized and investigated for their hypolipidemic and antiplatelet activity. Considering the hypolipidemic activity in rats at a dose of 80 mg/kg/day, some isomers were more potent than clofibrate at 150 mg/kg. Compoun