52735-71-4 Usage
Uses
Used in Biochemical Research:
H-PHE-CHLOROMETHYLKETONE HCL is utilized as a research tool for studying the function and mechanisms of serine proteases. Its ability to irreversibly bind to the active site of these enzymes aids scientists in understanding their roles in various biological processes.
Used in Cancer Treatment:
H-PHE-CHLOROMETHYLKETONE HCL is explored for its potential as a therapeutic agent in cancer treatment. By inhibiting serine proteases, it may help regulate processes related to tumor growth, invasion, and metastasis, offering a novel approach to managing cancer progression.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, H-PHE-CHLOROMETHYLKETONE HCL serves as a reactant in the synthesis of various organic compounds and drugs. Its unique chemical properties make it a valuable component in the development of new medications and therapeutic agents.
Used in Organic Synthesis:
H-PHE-CHLOROMETHYLKETONE HCL is employed as a reactant in organic synthesis across different chemical industries. Its versatility allows for the creation of a wide range of organic compounds, contributing to the advancement of chemical research and product development.
Check Digit Verification of cas no
The CAS Registry Mumber 52735-71-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,3 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 52735-71:
(7*5)+(6*2)+(5*7)+(4*3)+(3*5)+(2*7)+(1*1)=124
124 % 10 = 4
So 52735-71-4 is a valid CAS Registry Number.
52735-71-4Relevant academic research and scientific papers
An efficient and practical synthesis of the HIV protease inhibitor atazanavir via a highly diastereoselective reduction approach
Fan, Xing,Song, Yan-Li,Long, Ya-Qiu
, p. 69 - 75 (2012/12/31)
An efficient and practical synthesis of the HIV-1 protease inhibitor Atazanavir was developed by employing the diastereoselective reduction of ketomethylene aza-dipeptide isostere 10 as the key and final step. The high diastereoselectivity of the amino ketone reduction by lithium tri-iert-butoxyaluminum hydride in diethyl ether to afford the desired svn-1,2-amino alcohol structure was achieved by Felkin- Anh control as a result of the bulky and chiral N-(methoxycarbonyl)-L-tert-leucinyl moiety as the nitrogen protecting group. The coupling of the two key intermediates, N-(methoxycarbonyl)-L-tert-leucine acylated benzyl hydrazine 7 and chloromethyl ketone 9, via an SN2 reaction furnished the amino ketone 10 in high yield under our optimized conditions. Our new methodology features the late introduction of the S-hydroxyl group and the early acylation of benzyl hydrazine and chloromethyl ketone with N-(methoxycarbonyl)-L-tert-leucine, respectively, which confers high efficiency and easy purification.
