52735-71-4 Usage
General Description
H-PHE-CHLOROMETHYLKETONE HCL is a chemical compound that belongs to the class of chloromethyl ketones. It contains a chloromethyl (CH2Cl) group attached to a phenyl (C6H5) ring, and it is often used as a reactant in organic synthesis. H-PHE-CHLOROMETHYLKETONE HCL is commonly used as an inhibitor of proteolytic enzymes, particularly serine proteases, due to its ability to irreversibly bind to the active site of these enzymes. It has been studied for its potential applications in cancer treatment and as a tool in biochemical research. Additionally, it may have uses in the synthesis of pharmaceuticals and other organic compounds. Overall, H-PHE-CHLOROMETHYLKETONE HCL is a versatile compound with various potential applications in the fields of chemistry and biochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 52735-71-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,3 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 52735-71:
(7*5)+(6*2)+(5*7)+(4*3)+(3*5)+(2*7)+(1*1)=124
124 % 10 = 4
So 52735-71-4 is a valid CAS Registry Number.
52735-71-4Relevant articles and documents
An efficient and practical synthesis of the HIV protease inhibitor atazanavir via a highly diastereoselective reduction approach
Fan, Xing,Song, Yan-Li,Long, Ya-Qiu
, p. 69 - 75 (2012/12/31)
An efficient and practical synthesis of the HIV-1 protease inhibitor Atazanavir was developed by employing the diastereoselective reduction of ketomethylene aza-dipeptide isostere 10 as the key and final step. The high diastereoselectivity of the amino ketone reduction by lithium tri-iert-butoxyaluminum hydride in diethyl ether to afford the desired svn-1,2-amino alcohol structure was achieved by Felkin- Anh control as a result of the bulky and chiral N-(methoxycarbonyl)-L-tert-leucinyl moiety as the nitrogen protecting group. The coupling of the two key intermediates, N-(methoxycarbonyl)-L-tert-leucine acylated benzyl hydrazine 7 and chloromethyl ketone 9, via an SN2 reaction furnished the amino ketone 10 in high yield under our optimized conditions. Our new methodology features the late introduction of the S-hydroxyl group and the early acylation of benzyl hydrazine and chloromethyl ketone with N-(methoxycarbonyl)-L-tert-leucine, respectively, which confers high efficiency and easy purification.
