52751-24-3Relevant academic research and scientific papers
1,3-disubstituted-2-carboxyl quinolones: Highly potent and selective endothelin A receptor antagonists
Haesslein, Jean-Luc,Baholet, Isabelle,Fortin, Michel,Iltis, Alain,Khider, Jean,Periers, Anne Marie,Pierre, Christine,Vevert, Jean-Paul
, p. 1487 - 1490 (2000)
The design, synthesis, and in vitro biological activity of a series of 2-carboxy quinolone antagonists selective for the endothelin A receptor are presented. Introduction of a second acid group in position 3 of the quinolone ring increases dramatically the selectivity for ET(A). (C) 2000 Elsevier Science Ltd. All rights reserved.
