52763-33-4Relevant academic research and scientific papers
Heterocyclic esters of alkylphenyl benzopyrans
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, (2008/06/13)
Heterocyclic esters of benzopyrans represented by the formula STR1 wherein n is 1 or 2; each R and R1 are the same or different members of the group consisting of hydrogen or loweralkyl; R2 is loweralkyl; R3 is STR2 WITH Y
Anesthesia methods using benzopyrans and esters thereof as pre-anesthesia medication
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, (2008/06/13)
Improved anesthesia methods comprising pretreating a patient to be anesthetized with a benzopyran of formula I STR1 wherein, in the C ring, X is NR1, S, CH2 or STR2 R1 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, loweralkanoyl, cycloalkyloweralkyl, cycloalkylloweralkanoyl, cycloalkyl, haloloweralkyl, haloloweralkenyl, phenylloweralkyl, phenyloweralkenyl or phenyloweralkylnyl; m is an integer from 0 to 3, n is an integer from 0 to 3 and n + m = 2 or 3; or the C ring is quinuclidine ring STR3 R2 is loweralkyl; R3 is hydrogen or STR4 wherein Y is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4, Z is CH2, O, S or NR6, R6 being hydrogen or loweralkyl, with the limitation that when Z is O, S or NR5, the sum of a and b is 3 or 4, and R5 is hydrogen or loweralkyl; R4 is C1 -C20 straight or branched chain alkyl, cycloalkyl, or STR5 wherein Y is a straight or branched chain alkylene group having from one to ten carbon atoms, and each R7, R8 and R9 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof, with the limitation that when X is STR6 m = 2 and n = 2, R3 cannot be hydrogen.
Drugs derived from cannabinoids. 5. Δ(6a,10a) Tetrahydrocannabinol and heterocyclic analogs containing aromatic side chains
Winn,Arendsen,Dodge,Dren,Dunnigan,Hallas,Hwang,Kyncl,Lee,Plotnikoff,Young,Zaugg
, p. 461 - 471 (2007/10/05)
Ten new Δ(6a,10a) THC analogs with arylalkyl side chains, one with a dimethylaminoalkyl side chain, and six heterocyclic Δ(6a,10a) THC analogs [8 substituted 5,5 dimethyl 10 hydroxy 2 (2 propynyl) 1,2,3,4 tetrahydro 5H [1] benzo pyranol [4,3 c] pyridines] were prepared. They showed pharmacological activity as analgesics, tranquilizers, antihypertensives, and hypnotics and as antisecretory, antiulcer, and antidiarrheal agents. The most potent compounds had either a 1 methyl 4 (4 fluorophenyl) butyl or a 1,2 dimethyl 4 (4 fluorophenyl) butyl side chain.
