52770-39-5

Basic information

• Product Name: 2-d₁-3-bromothiophene
• Synonyms: 2-d₁-3-bromothiophene
• CAS NO: 52770-39-5
• Molecular Weight: 164.03
• Mol File: 52770-39-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-d₁-3-bromothiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-d₁-3-bromothiophene(52770-39-5)
• EPA Substance Registry System: 2-d₁-3-bromothiophene(52770-39-5)

Safety Data

• Hazardous Substances Data: 52770-39-5(Hazardous Substances Data)

Upstream product

• 24287-92-1 2-Bromo-3-iodothiophene 
• 3140-93-0 2,3-dibromothiophen 

Relevant articles and documents

Synthesis of 2,3-Substituted Thienylboronic Acids and Esters

A noncryogenic protocol for the synthesis of 2-substituted 3-thienylboronic acids and esters as well as 3-substituted 2-thienylboronic acids and esters has been developed. Electrophiles were introduced regiospecifically in the 2-position of 2,3-dibromothiophene and in the 3-position of 2-bromo-3-iodothiophene by halogen-magnesium exchange followed by quenching with electrophiles. Palladium-catalyzed borylation of the 2,3-substituted halothiophenes with pinacolborane and P(t-Bu)3 as ligand for Pd produced 9 and 10. The borylation protocol was tolerated by a range of functional groups; however, strongly electron-withdrawing substituents decreased the stability of the thienylboronic acids and esters.