52777-29-4 Usage
Uses
Used in Pharmaceutical Industry:
3-(3-amino-3-carboxypropyl)-1-methylpseudouridine is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique structure and functional groups enable it to serve as a building block in the development of novel drugs with potential applications in treating a wide range of diseases and conditions.
As a pharmaceutical intermediate, 3-(3-amino-3-carboxypropyl)-1-methylpseudouridine can be utilized in the synthesis of nucleoside analogs, which are known to have antiviral, anticancer, and immunosuppressive properties. Its presence in these compounds can potentially enhance their therapeutic efficacy and selectivity, leading to improved treatment outcomes for patients.
Furthermore, the compound's ability to form hydrogen bonds and interact with biological targets makes it a promising candidate for the development of new drugs targeting specific enzymes, receptors, or other cellular components. This can lead to the discovery of innovative treatments for various diseases, including those that are currently challenging to manage or cure.
Check Digit Verification of cas no
The CAS Registry Mumber 52777-29-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,7 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52777-29:
(7*5)+(6*2)+(5*7)+(4*7)+(3*7)+(2*2)+(1*9)=144
144 % 10 = 4
So 52777-29-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H21N3O8/c1-16-4-6(11-10(20)9(19)8(5-18)25-11)12(21)17(14(16)24)3-2-7(15)13(22)23/h4,7-11,18-20H,2-3,5,15H2,1H3,(H,22,23)/t7?,8-,9-,10-,11+/m1/s1
52777-29-4Relevant academic research and scientific papers
Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives
Chang, Yu-Cheng,Herath, Jayatilake,Wang, Tony H.-H.,Chow, Christine S.
, p. 2676 - 2686 (2008/09/21)
A series of 3-substituted uridine and pseudouridine derivatives, based on the naturally occurring 3-(3-amino-3-carboxypropyl) modification, were synthesized. Their aqueous solution conformations were determined by using circular dichroism and NMR spectroscopy. Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides. The dominating factor appears to be the glycosidic linkage (C- vs. N-glycoside) in determining the nucleoside conformation.
