52780-61-7Relevant academic research and scientific papers
Synthesis and characterization of iron trisphenolate complexes with hydrogen-bonding cavities
Adelhardt, Mario,Chalkley, Matthew J.,Heinemann, Frank W.,Sutter, Joerg,Scheurer, Andreas,Meyer, Karsten
supporting information, p. 2763 - 2765 (2014/04/03)
A new family of C3-symmetric ligands, featuring phenolate donors and a secondary coordination sphere, have been synthesized. We report the synthesis and subsequent coordination chemistry of these new tripodal N-anchored tris(phenolate) chelates, [tris(5-tert-butyl-3-N-carboxamide-2-hydroxybenzyl) amines] (H3RSalAmi), to iron(II), iron(III), and zinc(II). These electron-rich complexes have intramolecular hydrogen bonds, and therefore the potential to stabilize biologically relevant substrates in small-molecule activation chemistry.
2-(Aminomethyl)phenols, a new class of saluretic agents. I. Effect of nuclear substitution
Stokker,Deana,deSolms,Schultz,Smith,Cragoe Jr.,Baer,Ludden,Russo,Scriabine,Sweet,Watson
, p. 1414 - 1427 (2007/10/02)
A series of 2-(aminomethyl)phenols was synthesized and tested in rats and dogs for saluretic and diuretic activity. A number of these compounds exhibit a high order of activity on iv or po administration. The most active compounds belong to a subseries of 4-alkyl-6-halo derivatives of which 2,2(aminomethyl)-4-(1,1-dimethylethyl)-6-iodophenyl, is the most active. Compound 2 also possesses significant antihypertensive activity, an adjunctive pharmacological parameter which distinguishes 2 from the other compounds prepared in this series. In addition, 2 displays both topical saluretic and antiinflammatory activities.
