52786-40-0Relevant academic research and scientific papers
Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Co
Niswender, Kevin D.,Weaver, C. David,Nance, Kellie D.,Days, Emily L.,Coldren, Anastasia,Niswender, Colleen M.,Cho, Hyekyung P.,Weaver, C. David,Farmer, Tiffany D.,Lindsley, Craig W.,Niswender, Colleen M.,Lindsley, Craig W.,Blobaum, Anna L.,Lindsley, Craig W.
, p. 1611 - 1616 (2017)
A duplexed, functional multiaddition high throughput screen and subsequent optimization effort identified the first orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) noncompetitive antagonist. Antagonist 5d not only blocked e
