52789-90-9

Usage

Uses

Used in Pharmaceutical Research:
(5-BROMO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE is used as a research compound for exploring its potential biological activities and applications in the field of medicinal chemistry. Its unique structure may offer new insights and opportunities for the development of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (5-BROMO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE is used as a starting material or a structural component in the synthesis of new compounds with potential therapeutic properties. Its incorporation into various molecular frameworks may lead to the discovery of new drugs with improved efficacy and selectivity.
Used in Chemical Synthesis:
(5-BROMO-1-BENZOFURAN-2-YL)(4-CHLOROPHENYL)METHANONE can be utilized as a synthetic intermediate in the preparation of more complex organic molecules. Its bromo and chloro substituents provide opportunities for further functionalization and diversification of its chemical structure, which may be valuable in the synthesis of various target compounds.

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 1761-61-1 5-bromosalicyclaldehyde 

Downstream Products

• 82278-56-6 (5-bromobenzofuran-2-yl)-(p-chlorophenyl)methanol 
• 887605-92-7 C₂₄H₁₇BrClNO₃ 
• 887605-82-5 C₂₁H₁₉BrClNO₂ 
• 887605-86-9 C₂₁H₁₇BrClNO₃ 

Relevant academic research and scientific papers

Synthesis and antitubercular activity of 4-thiazolidinone derivatives incorporating benzofuran moiety

5-Bromo-1-benzofuran-2-yl(substituted phenyl) methanones (2a-e) were prepared by the reaction of 2-bromo-1-(phenyl) ethanones and 5-bromosalicylaldehyde in dimethylformamide in the presence of anhydrous potassium carbonate to maintain basic condition. Con

Reaction products of 5-bromobenzofuran-2-yl-aryl methanone and their antimicrobial activities

5-Bromobenzofuran-2-yl-aryl methanones (2a-e) were obtained by the reaction of 5-bromosalicylaldehyde 1 with 2-bromo-1-(aryl) ethanones. The condensation of compounds (2a-e) with hydroxylamine hydrochloride, thiosemicarbazide and aromatic amine such as an

Preparation of 2-, 3-, 4- and 7-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b] furans and their BLT1 and/or BLT2 inhibitory activities

Several 2-alkylcarbamoyl-1-alkylvinylbenzo[b]furans were designed to find a selective leukotriene B4 (LTB4) receptor antagonist. 2-(2-Alkylcarbamoyl-1-alkylvinyl)benzo[b]furans having a substituent group at the 3-position, 4-(2-alkylcarbamoyl-1-methylvinyl)benzo[b]furans having a substituent group at the 3-position, and 7-(2-alkylcarbamoyl-1-methylvinyl) benzo[b]furans and 3-(2-alkylcarbamoyl-1-alkylvinyl)benzo[b]furans were prepared and evaluated for LTB4 receptor (BLT1 and BLT 2) inhibitory activities. (E)-3-Amino-4-[2-[2-(3,4-dimethoxyphenyl) ethylcarbamoyl]-1-methylvinyl]benzo[b]furan ((E)-17c) showed potent and selective inhibitory activity for BLT2. On the other hand, (E)-7-(2-diethylcarbamoyl-1-methylvinyl)benzo[b]furan ((E)-27a) showed potent inhibitory activity for both BLT1 and BLT2. This journal is The Royal Society of Chemistry.