52795-02-5

Usage

Uses

Different sources of media describe the Uses of 52795-02-5 differently. You can refer to the following data:
1. Antidepressant.
2. Tametraline is a novel GABAA receptor blocker and a reactant in the preparation of (+)-sertraline and (-)-CP-52002.

InChI:InChI=1/C17H19N/c1-18-17-12-11-14(13-7-3-2-4-8-13)15-9-5-6-10-16(15)17/h2-10,14,17-18H,11-12H2,1H3/t14-,17+/m0/s1

Upstream product

• 52789-19-2 1-Methylimino-4-phenyl-1,2,3,4-tetrahydronaphthalin 
• 14578-68-8 4-phenyl-3,4-dihydronaphthalen-1(2H)-one 
• 52758-03-9 (+/-)-cis-1-Methylamino-4-phenyltetralin 
• 261776-39-0 methyl(4-phenyl-3,4-dihydro-2H-naphthalen-1-ylidene)amine 

Downstream Products

• 52789-19-2 1-Methylimino-4-phenyl-1,2,3,4-tetrahydronaphthalin 
• 339560-30-4 Ethyl-[4-phenyl-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-amine 
• 54308-60-0 Isopropyl-[4-phenyl-3,4-dihydro-2H-naphthalen-(1E)-ylidene]-amine 
• 52795-04-7 trans-dl-N-methyl-4-phenyl-1,2,3,4-tetrahydro-1-naphthylamine 
• 52758-03-9 (+/-)-trans-1-Methylamino-4-phenyltetralin 
• 52371-40-1 (+/-)-trans-1-Dimethylamino-4-phenyltetralin 
• 91797-70-5 (4S)-3,4-dihydro-4-phenyl-1(2H)-naphthalenone 
• 14578-68-8 4-phenyl-3,4-dihydronaphthalen-1(2H)-one 
• 52371-40-1 (+/-)-cis-1-Dimethylamino-4-phenyltetralin 

Relevant academic research and scientific papers

AN ORGANOCATALYTIC ASYMMETRIC SYNTHESIS OF ANTIDEPRESSANTS

The present invention relates to a short enantioselective synthesis of 1-amino aryl tetraline compounds of Formula 1 via nucleophilic enamine catalysis using organocatalyst such as proline. wherein R1 and R2 represent independent of each other hydrogen, (un)substituted or substituted amine; R3 and R4 represent independent of each other hydrogen or halogen.

Efficient kinetic resolution in the asymmetric hydrosilylation of imines of 3-substituted indanones and 4-substituted tetralones

Kinetic resolution of the N-methyl imines of 3-substituted indanones and 4-substituted tetralones could be accomplished by hydrosilylation with a chiral titanocene catalyst. N-Methyl imines of 4-substituted tetralones were resolved to yield, after hydrolysis of the unreacted starting materials, ketones with high ee's and the amine products with high diastereomeric and enantiomeric purity. The utility of this process was demonstrated in the synthesis of sertraline.