52799-86-7 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
H-TYR-OBZL is used as a research compound for its potential therapeutic properties, including antioxidant and anti-inflammatory effects, to develop new drugs for treating various conditions.
Used in Cancer Treatment:
H-TYR-OBZL is used as a therapeutic agent for its potential to treat cancer by modulating oncological signaling pathways and exhibiting synergistic anticancer effects when combined with conventional chemotherapeutic drugs.
Used in Neurodegenerative Disease Treatment:
H-TYR-OBZL is used as a therapeutic agent for its potential to treat neurodegenerative diseases by reducing oxidative stress and inflammation in the brain.
Used in Inflammatory Disorder Treatment:
H-TYR-OBZL is used as a therapeutic agent for its potential to treat inflammatory disorders by reducing inflammation and modulating immune responses.
Check Digit Verification of cas no
The CAS Registry Mumber 52799-86-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,7,9 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52799-86:
(7*5)+(6*2)+(5*7)+(4*9)+(3*9)+(2*8)+(1*6)=167
167 % 10 = 7
So 52799-86-7 is a valid CAS Registry Number.
InChI:InChI=1S/C16H17NO3/c17-15(10-12-6-8-14(18)9-7-12)16(19)20-11-13-4-2-1-3-5-13/h1-9,15,18H,10-11,17H2/t15-/m0/s1
52799-86-7Relevant academic research and scientific papers
MACROCYCLIZATION OF PEPTIDOMIMETICS
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Page/Page column 36; 40, (2019/10/19)
The invention provides an improved method of macrocyclization of peptidomimetics, as measured by isolated yields and product distribution, which comprises substitution of one or more of the backbone amide C=O bonds with a turn-inducing motif. The method is general with enhancements seen across a range of ring sizes (e.g. tri-, tetra-, penta- and hexapeptides). Specifically, the invention provides a peptidomimetic macrocycle comprising a carbonyl bioisosteric turn-inducing element having the structure: (I) wherein X is a heteroatom; and wherein R1 to R6 are each independently selected from alkyl, aryl, heteroaryl and H.
Solution-phase automated synthesis of tripeptide derivatives
Kuroda,Hattori,Kitada,Sugawara
, p. 1138 - 1146 (2007/10/03)
An improved general method for automated synthesis of tripeptides was developed, in which methanesulfonic acid (MSA) was used in place of trifluoroacetic acid (TFA), thus making it possible to avoid, 1) corrosion of the apparatus by strong acid vapor, 2) formation of emulsions, and 3) use of the restricted solvent, dichloromethane. As an application of the automated synthesis apparatus, 216 fragment tripeptide derivatives were synthesized systematically using the MSA method, in excellent yield and with increased efficiency.
