52803-70-0

Usage

Uses

Used in Organic Chemistry Research and Development:
2-(2-Chloro-benzyloxy)-Benzoic Acid is used as a reagent in organic chemistry for various research and development purposes. Its unique structure with both a benzoic acid group and a chloro-benzyl group allows for versatile applications in chemical synthesis and reactions.
Used in Chemical Synthesis:
In the chemical synthesis industry, 2-(2-Chloro-benzyloxy)-Benzoic Acid is used as a key intermediate or building block for the synthesis of more complex organic compounds. Its presence of both benzoic acid and chloro-benzyl groups makes it a valuable component in the creation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Development:
2-(2-Chloro-benzyloxy)-Benzoic Acid is utilized in the pharmaceutical industry as a precursor or intermediate in the development of new drugs. Its unique chemical structure can be modified or combined with other compounds to create potential therapeutic agents with specific pharmacological properties.

InChI:InChI=1/C14H11ClO3/c15-12-7-3-1-5-10(12)9-18-13-8-4-2-6-11(13)14(16)17/h1-8H,9H2,(H,16,17)/p-1

Upstream product

• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 119-36-8 methyl salicylate 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 95-49-8 2-methylchlorobenzene 
• 52803-83-5 2-(2-chloro-benzyloxy)benzoic acid methyl ester 

Relevant academic research and scientific papers

Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor

The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxybenzamides were discovered as novel SMS2 inhibitors through scaffold hopping and structural optimization. Among them, Ly93 as one of the most potent inhibitors exhibited IC50 values of 91 nM and 133.9 μM against purified SMS2 and SMS1 respectively. The selectivity ratio of Ly93 was more than 1400-fold for purified SMS2 over SMS1. The in vitro studies indicated that Ly93 not only dose-dependently diminished apoB secretion from Huh7 cells, but also significantly reduced the SMS activity and increased cholesterol efflux from macrophages. Meanwhile, Ly93 inhibited the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. The pharmacokinetic profiles of Ly93 performed on C57BL/6J mice demonstrated that Ly93 was orally efficacious. As a potent selective SMS2 inhibitor, Ly93 significantly decreased the plasma SM levels of C57BL/6J mice. Furthermore, Ly93 was capable of dose-dependently attenuating the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice treated with Ly93. In conclusion, we discovered a novel selective SMS2 inhibitor Ly93 and demonstrated its anti-atherosclerotic activities in vivo. The preliminary molecular mechanism-of-action studies revealed its function in lipid homeostasis and inflammation process, which indicated that the selective inhibition of SMS2 would be a promising treatment for atherosclerosis.

Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents

A series of novel salicylic acid derivatives containing metronidazole as Staphylococcus aureus Tyrosyl-tRNA synthetase (TyrRS) inhibitors have been synthesized and evaluated their biology activities as potential antibacterial agents. Among these compounds

Palladium-catalyzed intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides

Give me a ring? An efficient approach has been developed for the intramolecular decarboxylative coupling of arene carboxylic acids/esters with aryl bromides catalyzed by palladium (see scheme). From a synthetic viewpoint, this method is highly attractive because the catalyst loading is low, the optimized reaction conditions are mild, and the substrate scope is broad. Copyright