52806-72-1

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-aMino-4'-Methoxy-[1,1'-biphenyl]-4-yl)ethanone is used as an intermediate in the synthesis of 4'-Hydroxy Flurbiprofen (H942440), a metabolite of Flurbiprofen (F598700). Flurbiprofen is an anti-inflammatory drug that is also used for its analgesic properties. The intermediate compound contributes to the development of medications that help alleviate pain and reduce inflammation, making it an essential component in the pharmaceutical industry.

Upstream product

• 696-62-8 para-iodoanisole 
• 18640-58-9 3-nitro-4-bromoacetophenone 
• 52806-71-0 4-Acetyl-4'-methoxy-2-nitro biphenyl 

Relevant academic research and scientific papers

Substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid compounds

There are disclosed substituted benzoylbenzene-, biphenyl- and 2-oxazole- alkanoic acid derivatives and the pharmacologically acceptable salts thereof as inhibitors of PLA2 and lipoxygenase, and their use in the treatment of inflammatory condit

Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives as inhibitors of pla2 and lipoxygenase

There are disclosed compounds of the formula wherein A is a group having the formula STR1 wherein X is --N-- or STR2 Z is STR3 R1 is hydrogen, lower alkyl or phenyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzene ring, with the proviso that when X is --N--, Z is other than STR4 R3 is hydrogen or lower alkyl; n is 1-2; B is STR5 wherein Y is OR5 or N(OH)R8 ; R4 and R5 are each, independently, hydrogen or lower alkyl; R6 is hydrogen, halo or nitro; R7 is STR6 R8 is lower alkyl; m is 0-3; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

Substituted benzoylbenzene-, biphenyl- and 2-oxazole-alkanoic acid derivatives

There are disclosed compounds of the formula wherein A is STR1 n is 1-2; B is STR2 wherein R4 and R5 are each, independently, hydrogen or lower alkyl; R6 is hydrogen, halo or nitro; STR3 R8 is lower alkyl; m is

Phenylalkanoic acids

New compounds are described that are 2-(hydroxy substituted-4-biphenylyl)propionic acids. Processes of making and using them and pharmaceutical compositions containing them are also described. The compounds have, inter alia, antiinflammatory activity.