5281-28-7 Usage
Uses
Used in Pesticide Production:
Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromois used as a key ingredient in the production of pesticides for its strong disinfectant properties. The presence of bromine and fluorine atoms enhances the effectiveness of the pesticides in controlling pests and diseases in agriculture.
Used in Flame Retardant Production:
Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromois used as a flame retardant in various industries, such as plastics, textiles, and electronics. The bromine and fluorine atoms in the compound provide excellent fire resistance, making it a valuable component in flame retardant formulations.
Used in Pharmaceutical Industry:
Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromois used in the pharmaceutical industry for its disinfectant properties. It can be incorporated into various formulations, such as antiseptics and disinfectants, to help prevent the spread of infections and maintain hygiene in healthcare settings.
Safety Precautions:
Due to its toxic nature, it is important to handle Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[2,6-dibromowith caution and follow proper safety procedures when using it in any application. This includes wearing appropriate personal protective equipment, working in well-ventilated areas, and disposing of the chemical waste responsibly.
Check Digit Verification of cas no
The CAS Registry Mumber 5281-28-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,8 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5281-28:
(6*5)+(5*2)+(4*8)+(3*1)+(2*2)+(1*8)=87
87 % 10 = 7
So 5281-28-7 is a valid CAS Registry Number.
5281-28-7Relevant academic research and scientific papers
Structural optimization and biological evaluation of substituted bisphenol a derivatives as β-amyloid peptide aggregation inhibitors
Zhou, Yu,Jiang, Chunyi,Zhang, Yaping,Liang, Zhongjie,Liu, Wenfeng,Wang, Liefeng,Luo, Cheng,Zhong, Tingting,Sun, Yi,Zhao, Linxiang,Xie, Xin,Jiang, Hualiang,Zhou, Naiming,Liu, Dongxiang,Liu, Hong
experimental part, p. 5449 - 5466 (2010/11/05)
The aggregation of A? is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A? undergoes ?-helix/?-sheet intermediate structures during the conformational transition, and an A? aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A? but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A? 1?42-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.
