52814-89-8

Upstream product

• 150-19-6 O-methylresorcine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 52688-74-1 potassium 3-methoxyphenolate 

Downstream Products

• 1838-44-4 2-(4-'methoxyphenyl)-6-methoxybenzo[b]furan 
• 52814-52-5 3-(4-methoxyphenyl)-6-methoxy-1-benzofuran 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1613483-67-2 2-(4-chlorophenyl)-2-(3-methoxyphenoxy)-1-(4-methoxyphenyl)ethanone 
• 1579264-43-9 2-(4-chlorophenyl)-6-methoxy-3-(4-methoxyphenyl)benzofuran 
• 120990-50-3 <6-methoxy-3-(4-methoxyphenyl)-1-benzofuran-2-yl>(4-methoxyphenyl)methanone 
• 120990-51-4 [6-hydroxy-3-(4-hydroxyphenyl)-1-benzofuran-2-yl](4-hydroxyphenyl)methanone 

Relevant academic research and scientific papers

Cobalt-Catalyzed Reductive C-O Bond Cleavage of Lignin β-O-4 Ketone Models via in Situ Generation of the Cobalt-Boryl Species

An efficient and mild method for reductive C-O bond cleavage of lignin β-O-4 ketone models was developed to afford the corresponding ketones and phenols with PDI-CoCl2 as the precatalyst and diboron reagent as the reductant. The synthetic utility of the methodology was demonstrated by depolymerization of a polymeric model and gram-scale transformation. Mechanistic studies suggested that this transformation involves steps of carbonyl insertion, 1,2-Brook type rearrangement, β-oxygen elimination, and rate-limiting regeneration of the catalytic active Co-B species.

Facile synthesis of 3-aryl benzofurans, 3-aryl benzothiophenes, 2-aryl indoles and their dimers

The preparation of 3-aryl benzofuran and benzothiophenes and their dimers at 2-position and, 2-aryl indoles and their 3-position dimers preparation is described.

Ga(OTf)3-mediated synthesis of substituted benzofurans

A synthetic procedure, for the synthesis of a series of functionalized benzofurans 3–5 and benzonaphthofurans 6, starting from intermolecular O-alkylation of α-bromoaryl ketones 2 with potassium oxygenated phenoxides 1 followed by Ga(OTf)3-catalyzed direct intramolecular cyclodehydration of the resulting α-aryloxyaryl ketones, has been developed. The use of various metal triflates was investigated for a facile approach and efficient transformation. Pentacyclic benzophenanthrofurans 7 were prepared via photolytic annulations of 5.

Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-Disubstituted benzofurans

A highly efficient palladium-catalyzed α-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cyclodehydration of the resulting α-arylated ar

Benzofuran compounds, compositions, and methods

The present invention provides novel compound of the formula: wherein Rais —OH or —O—(C1-C4alkyl); R1ais —OH or —O—(C1-C4alkyl); n is 2 or 3; R2and R3are each independ

Methods of treating neuropeptide Y-associated conditions

This invention describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an analog of an obesity protein. This invention further describes methods of treating conditions associated with an excess of neuropeptide Y which coomprises administering an analog of an obesity protein in combination with a neuropeptide Y antagonist. This invention demonstrates that the obesity protein acts by reducing the production of neuropeptide Y by the hypothalamus.

Methods for treating resistant tumors

The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.

Methods of treating nueropeptide Y-associated conditions

This invention describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an obesity protein. This invention also describes methods of treating conditions associated with an excess of neuropeptide Y which comprises administering an obesity protein in combination with a neuropeptide Y antagonist. This invention demonstrates that the obesity protein acts by reducing the production of neuropeptide Y by the hypothalamus.

HETEROCYCLIC NEUROPEPTIDE Y RECEPTOR ANTAGONISTS

This invention provides methods for treating or preventing a condition associated with an excess of neuropeptide Y which methods comprise administration of one or more substituted benzofurans, benzothiophenes or indoles.