52820-26-5

Basic information

• Product Name: 2-Propenoyl chloride, 3-(4-hydroxyphenyl)-
• CAS NO: 52820-26-5
• Molecular Formula: C9H7ClO2
• Molecular Weight: 182.606
• Mol File: 52820-26-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propenoyl chloride, 3-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 3-(4-hydroxyphenyl)-(52820-26-5)
• EPA Substance Registry System: 2-Propenoyl chloride, 3-(4-hydroxyphenyl)-(52820-26-5)

Safety Data

• Hazardous Substances Data: 52820-26-5(Hazardous Substances Data)

Upstream product

• 7400-08-0 para-coumaric acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7719-09-7 thionyl chloride 

Downstream Products

• 29838-16-2 3-(4-hydroxyphenyl)-1-(p-tolyl)prop-2-en-1-one 
• 86293-51-8 1-(4-bromophenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 356568-33-7 1-(4-Hydroxy-phenyl)-3-(2,4,6-trimethyl-phenyl)-propenone 
• 66062-12-2 4-(4-hydroxy-phenyl)-6-naphtho[1,2-d]oxazol-2-yl-3-phenyl-3,4-dihydro-1H-pyrimidine-2-thione 
• 66061-65-2 4-(2-phenyl-5-naphtho[1,2-d]oxazol-2-yl-3,4-dihydro-2H-pyrazol-3-yl)-phenol 
• 66061-71-0 1-acetyl-5-(4-hydroxy-phenyl)-3-naphtho[1,2-d]oxazol-2-yl-4,5-dihydro-1H-pyrazole 
• 66062-11-1 4-(4-hydroxy-phenyl)-6-naphtho[1,2-d]oxazol-2-yl-3,4-dihydro-1H-pyrimidine-2-thione 
• 66061-59-4 4-(3-naphtho[1,2-d]oxazol-2-yl-4,5-dihydro-isoxazol-5-yl)-phenol 
• 72130-20-2 6,6'-bis-(4-hydroxy-phenyl)-1,1'-diphenyl-5,6,5',6'-tetrahydro-1H,1'H-4,4'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-bis-pyrimidine-2-thione 
• 72130-26-8 4,4'-(2,2'-diphenyl-3,4,3',4'-tetrahydro-2H,2'H-5,5'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-di-pyrazol-3-yl)-bis-phenol 
• 72130-14-4 6,6'-bis-(4-hydroxy-phenyl)-5,6,5',6'-tetrahydro-1H,1'H-4,4'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-bis-pyrimidine-2-thione 
• 72130-02-0 1,1'-diacetyl-5,5'-bis-(4-hydroxy-phenyl)-4,5,4',5'-tetrahydro-1H,1'H-3,3'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-bis-pyrazole 
• 72130-08-6 4,4'-(4,5,4',5'-tetrahydro-3,3'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-di-isoxazol-5-yl)-bis-phenol 
• 72129-96-5 3,3'-bis-(4-hydroxy-phenyl)-1,1'-benzo[1,2-d;4,5-d']bisoxazole-2,6-diyl-bis-propenone 

Relevant articles and documents

Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease

A series of novel Diallyl disulfide (DADS) derivatives were designed, synthesized and evaluated as chemical agents, which target and modulate multiple facets of Alzheimer's disease (AD). The results showed that the target compounds 5a-l and 7e-m exhibited significant anti-Aβ aggregation activity, considerable acetylcholinesterase (AChE) inhibition, high selectivity towards AChE over butyrylcholinesterase (BuChE), potential antioxidant and metal chelating activities. Specifically, compounds 7k and 7l exhibited highest potency towards self-induced Aβ aggregation (74% and 71.4%, 25 μM) and metal chelating ability. Furthermore, compounds 7k and 7l disaggregated Aβ fibrils generated by Cu2+-induced Aβ aggregation by 80.9% and 78.5%, later confirmed by transmission electron microscope (TEM) analysis. Besides, 7k and 7l had the strongest AChE inhibitory activity with IC50 values of 0.056 μM and 0.121 μM, respectively. Furthermore, molecular modelling studies showed that these compounds were capable of binding simultaneously to catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. All the target compounds displayed moderate to excellent antioxidant activity with ORAC-FL values in the range 0.546-5.86 Trolox equivalents. In addition, absorption, distribution, metabolism and excretion (ADME) profile and toxicity prediction (TOPKAT) of best compounds 7k and 7l revealed that they have drug like properties and possess very low toxic effects. Collectively, the results strongly support our assertion that these compounds could provide good templates for developing new multifunctional agents for AD treatment.

Coumarin derivative as well as preparation method and application thereof

The invention discloses a coumarin derivative as well as a preparation method and application thereof. The chemical structural formula of the coumarin derivative is represented by a formula (I) or a formula (II), wherein in the formula, R1 is H, CH3, OCH3

Coumarin glycoside compound, its preparation process and pharmaceutical composition and use thereof

The invention relates to a novel coumarin glycoside compound derived from esculine or skimmin and a synthesis method thereof, and application of the novel coumarin glycoside compound and 7-O-methylesculine as drugs in diseases related to diabetic angiopat