52821-19-9Relevant articles and documents
Synthesis, characterization, crystal structure and free radical scavenging activities of 2-(2-butylamine)-6-[(2-butylamine)amino]-5-nitro-1H-benzo[de]-isoquinoline-1,3(2H)-dione
Tang, Xiaolin,Zhang, Ye,Qin, Wen,Liao, Yongzhi
, p. 7457 - 7459 (2014)
2-(2-Butylamine)-6-[(2-butylamine)amino]-5-nitro-1H-benzo[de]-isoquinoline-1,3(2H)-dione (2) was synthesized and then characterized by FT-IR, NMR and elemental analysis. The crystal structure of compound 2 was investigated using X-ray diffraction and SHELXTL97 software and the result indicated that compound 2 crystallized in the monoclinic system, space group C2/c with a = 32.1094 (19), b = 7.1888 (4), c = 16.7750 (9) ?, V = 3827.2 (4) ?3; Z = 8. The free radical scavenging activity screening results showed that compound 2 exhibited good scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH?), with IC50 of 214.7 μM.
Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides
Li, Feng,Cui, Jingnan,Guo, Lianying,Qian, Xuhong,Ren, Weimin,Wang, Kewei,Liu, Fengyu
, p. 5114 - 5121 (2007)
A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In gene
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design
Miura, Takaaki,Fukami, Takaaki A.,Hasegawa, Kiyoshi,Ono, Naomi,Suda, Atsushi,Shindo, Hidetoshi,Yoon, Dong-Oh,Kim, Sung-Jin,Na, Young-Jun,Aoki, Yuko,Shimma, Nobuo,Tsukuda, Takuo,Shiratori, Yasuhiko
, p. 5778 - 5783 (2011)
Heat shock protein 90 (Hsp90) is a molecular chaperone which regulates maturation and stabilization of its substrate proteins, known as client proteins. Many client proteins of Hsp90 are involved in tumor progression and survival and therefore Hsp90 can be a good target for developing anticancer drugs. With the aim of efficiently identifying a new class of orally available inhibitors of the ATP binding site of this protein, we conducted fragment screening and virtual screening in parallel against Hsp90. This approach quickly identified 2-aminotriazine and 2-aminopyrimidine derivatives as specific ligands to Hsp90 with high ligand efficiency. In silico evaluation of the 3D X-ray Hsp90 complex structures of the identified hits allowed us to promptly design CH5015765, which showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models.
Design, synthesis and antitumor evaluation of new 1,8-naphthalimide derivatives targeting nuclear DNA
Liang, Gui-Bin,Wei, Jian-Hua,Jiang, Hong,Huang, Ri-Zhen,Qin, Jing-Ting,Wang, Hui-Ling,Wang, Heng-Shan,Zhang, Ye
, (2020/11/02)
Four series of new 3-nitro naphthalimides derivatives, 4(4a?4f), 5(5a?5i), 6(6a?6e) and 7 (7a?7j), were designed and synthesized as antitumor agents. Methyl thiazolyl tetrazolium (MTT) screening assay results revealed that some compounds displayed effecti
Naphthalimide fluorescent dye with great Stokes shift and long emission wavelength, and synthetic method and application thereof
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Paragraph 0043; 0044, (2017/07/20)
The invention provides a naphthalimide fluorescent dye with great Stokes shift and long emission wavelength, and a synthetic method and application thereof. 4-bromo-1,8-naphthalic anhydride is used as a starting material and subjected to nitration, azido reaction, reduction and the like with sodium azide, N-(2-aminoethyl)morpholine, n-butylamine and the like so as to obtain the target product, i.e., the naphthalimide fluorescent dye. The naphthalimide fluorescent dye has a structural formula as described in the specification. The synthetic method is simple in process and high in yield, has the advantages of high light stability, long emission wavelength and great Stokes shift compared with conventional naphthalimide fluorescent dyes, and can be applied to fields like luminescent materials, biofluorescent probes and biofluorescent imaging.
