52828-99-6Relevant academic research and scientific papers
Reaction of Biologically Active &β-Nitrostyrenes with o-Phenylenediamine: A New Route to the Synthesis of 2-Substituted Benzimidazoles
Latif, N.,Mishriky, N.,Assad, F. M.,Meguid, S. Abdel
, p. 872 - 874 (2007/10/02)
β-Nitrostyrenes (1) react with o-phenylenediamine in ethanol to give exclusively 2-substituted benzimidazoles (2) regardless of the nature and position of substituents in the phenyl ring.The correspondnig 2,3-dihydroperimidines (4) are readily obtained by reacting 1,8-diaminonaphthalene with benzaldehydes.Possible routes for the formation of 2 have been discussed.The nitrostyrenes (1) have been found to be toxic to fresh water snails and phytopathogenic fungi in high dilutions.
