52829-71-7

Usage

Classification

Aromatic amine compound

Usage

Marker for assessing the presence of illegal additives in food products

Specific Application

Marker for the illegal use of nitrofurans in animal husbandry

Health Concern

Potential carcinogen

Regulations

Banned for use in food-producing animals in many countries

Monitoring

Presence in food products is closely monitored and regulated

Purpose of Regulation

To ensure consumer safety and prevent harmful effects on human health

Upstream product

• 25379-67-3 N-[2-(5-methyl-oxazol-2-yl)-phenyl]-formamide 
• 4943-83-3 2-amino-N-(prop-2-yn-1-yl)benzamide 
• 118-48-9 isatoic anhydride 
• 16347-56-1 3-(prop-2-yn-1-yl)quinazolin-4(3H)-one 
• 52829-70-6 5-methyl-2-(2-nitro-phenyl)-oxazole 

Downstream Products

• 5221-67-0 5-methyl-2-phenyloxazole 
• 1148122-59-1 6-chloro-N-(2-(5-methyloxazol-2-yl)phenyl)-2-phenylpyrimidine-4-carboxamide 

Relevant academic research and scientific papers

AMIDE DERIVATIVES AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

Synthesis of 2-(-2-aminophenyl)-5-methyloxazole

Ring opening of isatoic anhydride by prop-2-ynylamine yielded the corresponding amide, which was cyclised under basic conditions to give 2-(2-aminophenyl)-5-methyloxazole 5.