52829-92-2

Basic information

• Product Name: methyl-(5-methyl-thiazol-2-yl)-phenyl-amine
• CAS NO: 52829-92-2
• Molecular Weight: 204.296
• Mol File: 52829-92-2.mol

Chemical Properties

• CAS DataBase Reference: methyl-(5-methyl-thiazol-2-yl)-phenyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: methyl-(5-methyl-thiazol-2-yl)-phenyl-amine(52829-92-2)
• EPA Substance Registry System: methyl-(5-methyl-thiazol-2-yl)-phenyl-amine(52829-92-2)

Safety Data

• Hazardous Substances Data: 52829-92-2(Hazardous Substances Data)

Upstream product

• 5153-67-3 nitrostyrene 
• 137768-73-1 1-isothiocyanatopropa-1,2-diene 
• 100-61-8 N-methylaniline 
• 52829-90-0 methyl-(5-methylene-4,5-dihydro-thiazol-2-yl)-phenyl-amine 

Relevant articles and documents

Real Multicomponent Reactions: Synthesis of Highly Substituted 2-Aminothiazoles

Allenyl isothiocyanates, which can be easily generated by flash vacuum pyrolysis, are known to readily form 1,3-thiazoles with various nucleophiles. This is also true for heterocyclic aromatic amines and sterically hindered amines that are in other aspects used as non-nucleophilic bases. The chemistry of these synthetically useful cumulenes is now expanded to the field of multicomponent reactions with the mentioned amines and selected electrophiles. In an efficient, catalyst-free three-component reaction (3-CR) sequence, highly substituted heterocyclic compounds are formed containing the 2-amino-1,3-thiazole skeleton. The reaction conditions and mechanisms leading to these potentially bioactive molecules were investigated and optimized for the synthesis of a small compound library.