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52842-47-4

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52842-47-4 Usage

General Description

(+)-Columbianetin is a natural chemical compound found in several plant species, including the Colombian medicinal plant Esenbeckia pumila. It is a type of coumarin, which is a class of compounds known for their potential medicinal properties. Studies have shown that (+)-columbianetin has antioxidant and anti-inflammatory properties, making it a potentially beneficial compound in the treatment of inflammatory conditions and as a natural remedy for oxidative stress-related diseases. Additionally, it has been studied for its potential as a therapeutic agent for neurological disorders, including Alzheimer's disease. Research on (+)-columbianetin is still ongoing, but its promising pharmacological activities make it a compound of interest in the field of natural medicine and drug development.

Check Digit Verification of cas no

The CAS Registry Mumber 52842-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,8,4 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52842-47:
(7*5)+(6*2)+(5*8)+(4*4)+(3*2)+(2*4)+(1*7)=124
124 % 10 = 4
So 52842-47-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H14O4/c1-14(2,16)11-7-9-10(17-11)5-3-8-4-6-12(15)18-13(8)9/h3-6,11,16H,7H2,1-2H3/t11-/m1/s1

52842-47-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-columbianetin

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52842-47-4 SDS

52842-47-4Downstream Products

52842-47-4Relevant articles and documents

Design, synthesis and biological evaluation of novel osthole-based derivatives as potential neuroprotective agents

Zhang, Li,Wu, Yuhang,Yang, Guixiang,Gan, Haixian,Sang, Dayong,Zhou, Jiye,Su, Lin,Wang, Rui,Ma, Lei

, (2020/11/03)

A total of 26 compounds based on osthole skeleton were designed, synthesized. Their cytoprotective abilities of antioxidation, anti-inflammation and Aβ42(Amyloid β-protein 42)-induced neurotoxicity were evaluated by MTT assays. Mechanism of the action of selected compounds were investigated by molecular docking. AlogP, logS and blood–brain barrier (BBB) permeability of all these compounds were simulated by admetSAR. Most of the compounds showed better antioxidative and anti-inflammatory activities compared with osthole, especially OST7 and OST17. The compound OST7 showed relative high activity in neuroprotection against H2O2 (45.7 ± 5.5%), oxygen glucose deprivation (64.6 ± 4.8%) and Aβ42 (61.4 ± 5.2%) at a low concentration of 10 μM. EC50 of selected compounds were measured in both H2O2 and OGD induced cytotoxicity models. Moreover, NO inhibiting ability of OST17(50.4 ± 7.1%) already surpassed the positive drug indomethacin. The structure activity relationship study indicated that introduction of piperazine group, tetrahydropyrrole group and aromatic amine group might be beneficial for enhancement of osthole neuroprotective properties. Molecular docking explained that the reason OST7 exhibited relatively stronger neuroprotection against Aβ because of the greater area of interactions between molecule and target protein. OST7 and OST17 both provided novel methods to investigate osthole as anti-AD drugs.

Accessing columbianetin-containing natural products via a domino on-water, in-water process

Beare, Kaitlin D.,McErlean, Christopher S.P.

supporting information, p. 1056 - 1058 (2013/04/10)

A domino on-water, in-water process has been developed for the rapid and efficient synthesis of (±)-columbianetin. This highlights the operational simplicity of on-water chemistry. The domino process forms the key step in the synthesis of the columbianetin-containing natural products (±)- columbianetin acetate, (±)-zosimin, (±)-libanorin and (±)-angelmarin.

Asymmetric synthesis of 2-Substituted dihydrobenzofurans and 3-hydroxydihydrobenzopyrans through the enantioselective epoxidation of O-silyl-protected ortho-allylphenols

Jiang, Hang,Sugiyama, Takaya,Hamajima, Akinari,Hamada, Yasumasa

, p. 155 - 162 (2011/03/22)

The Shi-type epoxidation of O-tert-butyldiphenylsilyl (TBDPS) protected o-allylphenols serves as an efficient strategy to construct the dihydrobenzofurans and dihydrobenzopyrans in up to 97% ee. This methodology led to the enantioselective synthesis of (+)-marmesin, (-)-(3′R)-decursinol, and (+)-lomatin.

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