52843-77-3

Basic information

• Product Name: {[(trifluoromethyl)sulfonyl]ethynyl}benzene
• CAS NO: 52843-77-3
• Molecular Formula: C₉H₅F₃O₂S
• Molecular Weight: 234.195
• Mol File: 52843-77-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 255.4°C at 760 mmHg
• Flash Point: 108.3°C
• Density: 1.47g/cm³
• Vapor Pressure: 0.0261mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: {[(trifluoromethyl)sulfonyl]ethynyl}benzene(CAS DataBase Reference)
• NIST Chemistry Reference: {[(trifluoromethyl)sulfonyl]ethynyl}benzene(52843-77-3)
• EPA Substance Registry System: {[(trifluoromethyl)sulfonyl]ethynyl}benzene(52843-77-3)

Safety Data

• Hazardous Substances Data: 52843-77-3(Hazardous Substances Data)

Usage

General Description

{[(trifluoromethyl)sulfonyl]ethynyl}benzene is a chemical compound with the molecular formula C10H5F3O2S. It is a sulfonyl-substituted benzene derivative with a trifluoromethyl group and an ethynyl group attached to it. {[(trifluoromethyl)sulfonyl]ethynyl}benzene is commonly used in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals. It is also utilized as a building block in the production of other specialty chemicals and materials. Additionally, {[(trifluoromethyl)sulfonyl]ethynyl}benzene may exhibit unique chemical properties that make it suitable for use in specific applications in the fields of chemistry, medicine, and materials science.

Upstream product

• 6738-06-3 phenylethynylmagnesium bromide 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 536-74-3 phenylacetylene 
• 2926-29-6 Langlois reagent 
• 1402548-38-2 phenyl(phenylethynyl)iodonium 2,2,2-trifluoroacetate 
• 79069-32-2 phenyl(phenylethynyl)iodonium tosylate 
• 52208-94-3 1-butyl trifluormethyl sulfone 
• 4440-01-1 lithium phenylacetylide 

Downstream Products

• 119353-25-2 1-((Z)-1-Phenyl-2-trifluoromethanesulfonyl-vinyl)-pyrrolidine 
• 121290-04-8 (E)-3-Diethylamino-3-phenyl-2-trifluoromethanesulfonyl-propenal 
• 81227-07-8 2-triflyl-1-ethoxy-1-phenylethene 
• 121290-10-6 (E)-4-Dimethylamino-4-phenyl-3-trifluoromethanesulfonyl-but-3-en-2-one 
• 121290-02-6 (E)-3-Diisopropylamino-3-phenyl-2-trifluoromethanesulfonyl-propenal 
• 105066-08-8 2-(Methylphenylamino)-3,4-diphenyl-5-<(trifluormethyl)sulfinyl>furan 
• 35896-48-1 1-phenyl-2-((trifluoromethyl)sulfonyl)ethan-1-one 
• 27975-64-0 (3-ethoxybut-1-yn-1-yl)benzene 
• 176312-42-8 2-((Z)-1-Phenyl-2-trifluoromethanesulfonyl-vinyl)-furan 
• 184713-60-8 2-((E)-1-Phenyl-2-trifluoromethanesulfonyl-vinyl)-furan 

Relevant articles and documents

On Reactions of 5-Imino-N,4-diaryl-4,5-dihydro-1,2,4-thiadiazol-3-amines with Phenylethynyl Sulfones

Abstract: N-Arylthioureas were reacted with hydrogen peroxide to synthesize 5-imino-N,4-diaryl-4,5-dihydro-1,2,4-thiadiazol-3-amines (Ar = Ph, p-Tol, 4-BrC6H4). The products undewent 1,3-dipolar cycloaddition to (R-ethynyl)sulfonyl b

Method for preparing perfluoroalkyl sulfonyl alkyne without metal or additive

The invention discloses a method for preparing perfluoroalkyl sulfonyl alkyne without metal or additive. The method comprises the steps that alkynyl aryl trivalent iodized salt and sodium perfluoroalkane sulfinate are mixed, reacting is conducted at minus 80 DEG C to minus 60 DEG C for 5 min to 24 h, separation and purification are conducted, and perfluoroalkyl sulfonyl alkyne is obtained. Sodium perfluoroalkane sulfinate can be prepared through sulfinatodehalogenation from perfluoroalky iodide very conveniently. The method is low in cost, diverse in type, rich in raw material source, mild in reaction condition, easy to implement and capable of being implemented in water and organic mixed solvent. The method for conducting perfluoroalkyl sulfonylation on alkynyl aryl trivalent iodized salt directly through sodium perfluoroalkane sulfinate without metal or any additive has good universality. According to the method, the raw materials are easy to obtain, the reaction condition is mild, the selectivity is good, the yield is high, the requirement on instruments and equipment is low, the technological operation is easy, and the method is expected to be used for synthesizing multiple trifluoromethoxy-containing pesticides, medicines, drug intermediates and novel materials on a large scale.

Radical Alkynyltrifluoromethylation of Alkenes Initiated by an Electron Donor-Acceptor Complex

Radical alkynyltrifluoromethylation of alkenes with actylenic triflones has been achieved. This radical chain reaction is initiated by a catalytic amount of an electron-donor-acceptor complex composed of Togni’s reagent and N-methylmorpholine. This transf