52853-46-0Relevant articles and documents
Quantitative activity-activity relationship (QAAR) driven design to develop hydroxamate derivatives of pentanoic acids as selective HDAC8 inhibitors: synthesis, biological evaluation and binding mode of interaction studies
Adhikari, Nilanjan,Amin, Sk. Abdul,Das, Sanjib,Ghosh, Balaram,Jha, Tarun,Routholla, Ganesh,Trivedi, Prakruti,Vijayasarathi, Dhanya
, p. 17149 - 17162 (2021)
Histone deacetylase 8 (HDAC8) has been implicated as a potential drug target of many diseases including cancer. HDAC8 isoform selectivity over other class-I HDACs is a major concern nowadays. In this work, a series of pentanoic acid based hydroxamates wit