528533-16-6

Upstream product

• 7478-12-8 3,4-methylenedioxy-deoxybenzoin-(E)-oxime 
• 103-82-2 phenylacetic acid 
• 80824-83-5 methyl N-(1,3-benzodioxol-5-yl)-carbamodithioate 
• 126266-77-1 3,5-methylenedioxy-α-phenylacetophenone 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 103-80-0 phenylacetyl chloride 
• 60-29-7 diethyl ether 
• 10026-13-8 phosphorus pentachloride 

Relevant academic research and scientific papers

Zinc mediated facile amide formation : Application to alkyl, aryl, heterocycle, carbohydrate and amino acids

Synthesis of alkyl, aryl, heterocyclic, carbohydrate and amino acid amides using activated zinc is described. The recovery and reuse of the zinc makes the procedure more economic.

Dithiocarbamate and DBU-promoted amide bond formation under microwave condition

Dithiocarbamate and DBU-promoted amide bond formation under microwave condition has been reported. The versatility of this synthetic protocol has been demonstrated with various carboxylic acids and different dithiocarbamates. The products thus obtained ha

Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: Structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins

A series of 3-indoleacrylonitrile tyrphostins, 2-chloro-3- phenylquinolines, and 3-arylquinoxalines were prepared and tested for inhibition of platelet-derived growth factor receptor tyrosine kinase (PDGF- RTK) activity. The potency of the inhibitors was found to be quinoxalines > quinolines > indoles. Lipophilic groups (methyl, methoxy) in the 6 and 7 positions and phenyl at the 3 position of quinoxalines and quinolines were essential for potency, in contrast to the hydrophilic catechol group in tyrphostins active against EGFR kinase inhibition at different sites. The inhibitors showed selectivity for PDGF and were not active against EGF receptor and HER-2/c-ErbB-2 receptor.