52856-19-6

Basic information

• Product Name: 1-(2,6-dimethoxyphenyl)-2-phenylethanone
• Synonyms: 1-(2,6-dimethoxyphenyl)-2-phenylethanone
• CAS NO: 52856-19-6
• Molecular Weight: 256.301
• Mol File: 52856-19-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(2,6-dimethoxyphenyl)-2-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-dimethoxyphenyl)-2-phenylethanone(52856-19-6)
• EPA Substance Registry System: 1-(2,6-dimethoxyphenyl)-2-phenylethanone(52856-19-6)

Safety Data

• Hazardous Substances Data: 52856-19-6(Hazardous Substances Data)

Upstream product

• 1466-76-8 2-6-dimethoxybenzoic acid 
• 140-29-4 phenylacetonitrile 
• 101-97-3 Ethyl 2-phenylethanoate 
• 151-10-0 1,3-Dimethoxybenzene 
• 96-09-3 styrene oxide 
• 60319-07-5 trifluoromethanesulfonic acid 2,6-dimethoxyphenyl ester 
• 6921-34-2 benzylmagnesium chloride 
• 1989-53-3 2,6-dimethoxybenzoyl chloride 

Downstream Products

• 53847-87-3 5-methoxyisoflavone 

Relevant articles and documents

Preparation method of aryl ketone

The invention discloses a preparation method of aryl ketone. The preparation method comprises the following steps: mixing a phenyl epoxy compound, aryl trifluoromethanesulfonate, a phosphine ligand, a nickel source, alkali and an organic solvent, and conducting reacting in one step under the protection of inert gas to generate aryl ketone. The preparation method disclosed by the invention is simple in process, mild in conditions and low in cost, and paves a way for large-scale industrial production application, such as drug synthesis or natural product synthesis application, of aryl ketone serving as an important organic reaction intermediate.

An improved palladium(II)-catalyzed method for the synthesis of aryl ketones from aryl carboxylic acids and organonitriles

A palladium(II)-catalyzed decarboxylative protocol for the synthesis of aryl ketones has been developed. The addition of TFA was shown to improve the reaction yield and employing THF as solvent enabled the use of solid nitriles and in only a small excess. Using this method, five different benzoic acids reacted with a wide range of nitriles to produce 29 diverse (hetero)aryl ketone derivatives in up to 94% yield.