528560-17-0Relevant articles and documents
Synthesis and spectroscopic characterization of cyclobutyl hydantoins
Caturelli, Juan,Martini, M. Florencia,Fabian, Lucas,Moltrasio, Graciela Y.,Moglioni, Albertina G.
, p. 495 - 502 (2018/07/06)
The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of biological properties to different derivatives. Thus, synthetic methods have been developed to obtain such molecules. Herein, we describe the heterocyclization process to obtain imidazolidine-2,4-diones (hydantoin compounds) from methylcyclobutyl ketones and cyclobutanones derived from (?)-(1S)-α-pinene and (?)-(1S)-verbenone through the Bucherer-Berg reaction. The methylcyclobutyl hydantoins and the spirohydantoin obtained were fully characterized, determining their absolute stereochemistry by nuclear magnetic resonance experiments and theoretical calculations.
Enantiodivergent synthesis of cyclobutyl-(Z)-α,β-dehydro-α-amino acid derivatives from (-)-cis-pinononic acid
Aguado, Gemma P.,Moglioni, Albertina G.,Ortuno, Rosa M.
, p. 217 - 223 (2007/10/03)
The two enantiomers of the title dehydroamino acids (DHAAs) have been synthesized through respective Wadsworth-Emmons condensations of a suitable phosphonate with enantiomeric cyclobutyl aldehydes. These compounds, in turn, were prepared by selective mani
