528560-94-3

Usage

Uses

Used in Pharmaceutical Industry:
Telmisartan ethyl ester is used as an impurity in the synthesis of Telmisartan, an angiotensin II receptor antagonist, for the treatment of hypertension and cardiovascular diseases. The presence of this impurity is crucial for the development and production of Telmisartan, as it contributes to the overall synthesis process and the final product's efficacy.

Upstream product

• 6091-64-1 2-bromobenzoic acid ethyl ester 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 
• 1197049-19-6 ethyl 3-(4-((1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazol-3'-yl)methyl)phenyl)propiolate 
• 74-86-2 acetylene 

Downstream Products

• 144701-48-4 telmisatran 

Relevant academic research and scientific papers

AN IMPROVED PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE TELMISARTAN

The present invention relates to an improved process for the preparation of substantially pure Telmisartan in polymorphic form A.

PROCESS FOR THE PREPARATION OF PURE 4'-[4-METHYL-6-(1-METHYL-2-BENZIMIDAZOLYL)-2-PROPYL-1-BENZIMIDAZOLYL]METHYL]-2-BIPHENYLCARBOXYLIC ACID

The present invention relates to the purification of Telmisartan (I) from a mixture of water immiscible solvent and polar aprotic solvent, which results in the Telmisartan with the purity of above 99.5% by HPLC. Further, the precipitation process of the present invention improves flowability of crystallized product, ease of filtration from the crystalline medium, thereby increasing the yield, decreasing the cost and avoiding the drying problems.

A process for the preparation of Telmisartan.

The present invention relates to a process for the preparation of Telmisartan esters and Telmisartan and intermediates for the synthesis thereof.

Process for the preparation of telmisartan

A process for the preparation of telmisartan (I) and novel intermediates useful for its synthesis.