528597-08-2

Upstream product

• 528597-01-5 ethyl 2-amino-6-[2-(4-ethoxycarbonylphenyl)ethyl]-3-nitroisonicotinate 
• 528596-98-7 ethyl 4-(5-ethoxycarbonyl-3,5-dioxopentyl)benzoate 
• 174666-19-4 4-(3-oxobutyl)benzoic acid ethyl ester 

Downstream Products

• 528597-31-1 diethyl N-[4-[2-(2,4-diaminopyrido[3,4-d]pyrimidin-6-yl)ethyl]benzoyl]-L-glutamate 
• 528597-19-5 diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate 
• 1028269-33-1 4-[2-(2,4-diamino-pyrido[3,4-d]pyrimidin-6-yl)-ethyl]-benzoic acid 
• 528597-17-3 4-[2-(2-amino-4-oxo-3,4-dihydro-pyrido[3,4-d]pyrimidin-6-yl)-ethyl]-benzoic acid 
• 528597-28-6 methyl 4-[2-(2,4-diaminopyrido[3,4-d]pyrimidin-6-yl)ethyl]benzoate 
• 528597-14-0 methyl 4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]benzoate 
• 528597-26-4 methyl 4-[2-(5-amino-4-cyanopyridin-2-yl)ethyl]benzoate 
• 528597-11-7 methyl 4-[2-(5-amino-4-carbamoylpyridin-2-yl)ethyl]benzoate 

Relevant academic research and scientific papers

Synthesis of 7-Aza-5,8,10-trideazafolic acid and its 4-amino-derivative as potential antifolates

o-Aminoamide 8, an intermediate in our multistep synthesis of the title compounds was prepared from 1,3-diketone 3. The following condensation of 8 with chloroformamidine-HCl (9) gave pyrido[3,4-d]pyrimidine 10. Dehydratisation of amide 8 led to o-aminonitrile 15, which was cyclocondensated with guanidine (16) to yield pyrido[3,4-d]pyrimidine-2,4-diamine 17. Coupling of the acids 11 and 18 with diethyl L-glutamate (12) and following saponification provided 7-aza-5,8,10-trideazafolic acid 14 and its 4-amino-derivative 20.