528609-61-2

Upstream product

• 95340-88-8 (3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one 
• 115269-21-1 (2R,6S)-4-oxatricyclo[5.2.1.0^2,6]dec-8-en-3-one 
• 591-51-5 phenyllithium 

Downstream Products

• 90366-21-5 (+)-(R)-5-phenyl-furan-2-(5H)-one 
• 1955-39-1 5-phenyl-3H-furan-2-one 
• 528609-80-5 (1R,2S,5R,6R,7S)-5-Phenyl-4-oxa-tricyclo[5.2.1.0^2,6]dec-8-en-3-one 

Relevant academic research and scientific papers

Enantiodivergent syntheses of γ-substituted butenolides with tertiary and quaternary asymmetric centers

Continuous nucleophilic addition with several organometallic reagents to tricyclic lactone (-)-1 proceeded diastereoselectively. Newly generated tertiary and quaternary asymmetric centers were controlled by the order in which the nucleophilic reagents were added. Using this methodology, enantiodivergent syntheses of several γ-substituted butenolides with tertiary and quaternary asymmetric centers were established from a single chiral material.